IndraLab

Statements

SIRT1 binds CTNNB1 and LEF1. 4 / 4
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"Interestingly, SIRT1 interaction with both β-catenin and LEF-1 is increased in response to high glucose, but these complexes are disrupted in the presence of LiCl."
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"Strikingly, LiCl disrupted the SIRT1/LEF-1 complexes induced by glucose, most likely owing to competition for LEF-1 binding between β-catenin (accumulated by LiCl) and SIRT1."
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"Collectively, the results indicate that combined glucose and LiCl treatment increases p300-LEF-1-β-catenin interaction while preventing SIRT1-LEF-1 and SIRT1-β-catenin interaction and suggest that inc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mechanistically, DBC1 stabilizes LEF1–β-catenin interaction by inhibiting SIRT1-mediated β-catenin deacetylation, thereby enhancing LEF1–β-catenin complex formation and long-range chromatin looping at the PROX1 locus."
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