IndraLab

Statements


MDM2 inhibits TP53-R175H. 4 / 4
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"These results indicate that CTM restores mutant p53 R175H function to wt like p53, thus activating the induction of MDM2, which then binds to and negatively regulates p53 R175H."

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"This experiment demonstrated that the absence of CHIP does not impair HSP70 moderated, MDM2 dependent degradation of p53 R175H (XREF_SUPPLEMENTARY)."

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"Ectopic expression of MDM2 clearly down-regulated mutp53 R175H in H1299 cells co-transfected with vectors expressing mutp53 R175H and MDM2 (XREF_FIG), which is consistent with previous reports."

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"Contrary to CHIP mediated degradation, MDM2 dependent degradation of p53 R175H is partially inhibited by HSP70 overexpression (XREF_FIG), while overexpression of dominant negative HSP70 K71S mutant protein stimulates p53 R175H degradation (XREF_FIG)."