IndraLab

Statements

CYLD activates TBK1. 10 / 10
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"CYLD deficiency causes constitutive activation of TBK1 and IKKε in DCs, and the CYLD-deficient DCs and MEFs are hyper-responsive to VSV in IFNβ induction xref ."
27012466
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"As expected, expression of CYLD resulted in reduction of the ubiquitination levels of overexpressed TBK1, further indicating that CYLD activity targeted TBK1 (XREF_FIG)."
25923723
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"MIB1/2, Nrdp1, CYLD, A20-TAX1BP1-ABIN1 complex and RNF11-TAX1BP1 complex modulate K63-linked ubquitination of TBK1."
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"Because CYLD deficiency causes constitutive activation of IKKε and TBK1, this DUB has been suggested to play an essential role in preventing the aberrant activation of these kinases during the induction of type1 interferon that occurs during viral infection ( xref )."
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"Together, these results suggest that CYLD targets TBK1 or its downstream molecules to negatively regulate antiviral response."
24493797
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"Although this phenotype may involve ubiquitin dependent activation of RIG-I, CYLD also directly targets TBK1 and IKKepsilon to inhibit their ubiquitination 79."
27012466
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"Genetic deficiency in the DUB CYLD causes constitutive activation of TBK1 and IKKepsilon in DCs, rendering the cells hyperresponsive to VSV induced type I IFN expression XREF_BIBR, XREF_BIBR."
27012466
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"CYLD deficiency causes constitutive activation of TBK1 and IKKepsilon in DCs, and the CYLD deficient DCs and MEFs are hyper-responsive to VSV in IFNbeta induction 80."
27012466
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"CYLD deficiency causes constitutive activation of IKKepsilon and TBK1, which is associated with hyper-induction of IFNs in virus infected cells."
18467330
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"Because CYLD deficiency causes constitutive activation of IKKepsilon and TBK1, this DUB has been suggested to play an essential role in preventing the aberrant activation of these kinases during the induction of type1 interferon that occurs during viral infection."
19489724