IndraLab

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Lipopolysaccharide bound to TLR4 activates JNK. 3 / 3
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"Binding of LPS to TLR4 on KC, activating NF-kB, MAPK, ERK1, p38, JNK, and IRF3, induces the production of inflammatory cytokines and type I IFN, contributing to tissue damage, increase in leukocyte infiltration, and secretion of profibrogenic cytokines."
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"Studies in non hepatic cells suggest that LPS binding to toll like receptor 4 protein (TLR4) results in the activation of the transcription factor, NF-kappaB and the stress activated kinases, JNK and p38 MAPK."
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"For example, LPS binds to TLR4 mediated by myeloid differentiation primary response protein 88 (MyD88), and activates c-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NFkappaB), two important inflammatory signaling molecules 17."
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