IndraLab

Statements

Phosphorylated SOS1 is inactive. 3 / 3
3 |
signor
"ERK activation was sufficient for the SOS1 phosphorylation and resulting inhibition of EGF-induced Ras activation. This result also showed that SOS1 could be phosphorylated by ERK in the absence of association with EGFR at the plasma membrane, which is a phosphotyrosine-dependent process."
20724475
signor
"For example, inactivation of sos through phosphorylation by the downstream mapk"
7478566
signor
"These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3"
10197981