IndraLab

Statements

BRAF-V599E activates ERK. 3 / 3
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"However, although most melanoma cells cultured under 2D conditions display active ERK1/2 induced by a ca BRAF V599E mutation, we found that melanoma cell MEK1-ERK1/2 signaling depended on integrin alphav within 3D-collagen."
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"This V599E BRAF mutant shows highly elevated kinase activity and stimulates ERK activity constitutively independent of RAS activation."
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"Oncogenic RAS mutations and the BRAF V599E mutation induce constitutive ERK activity when cDNAs encoding the mutant versions are expressed in tissue culture cells."
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