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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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Cytokine activates JNK. 8 / 121
| 111
sparser
"We observed that overexpression of wild-type MEKK-1, but not of a kinase dead MEKK-1 mutant, resulted in potentiation of cytokine-induced JNK activation, inhibitor of kappaB (IkappaB) degradation, and cell death."
sparser
"P38 MAPK and c-Jun N-terminal kinase (JNK), two members of the MAPK superfamily, are activated by cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β, or G protein-coupled receptors, and have an important role in inflammation and apoptosis in response to stress ( xref )."
sparser
"In the present study, we provide evidence of differential signaling mechanisms for the activation of JNK by palmitate and cytokines."
sparser
"Furthermore, JNK and p38 MAPK signalling molecules are predominantly activated depending upon the inflammatory cytokines and environmental stress, which ultimately helps in cell differentiation and apoptosis [ xref ]."
sparser
"Taken together, HBV or HCV components and pro-inflammatory cytokine additively activate JNK to shift Smad phospho-isoform signaling from the tumor-suppressive TβRI/pSmad3C pathway to the carcinogenic JNK/pSmad3L pathway together with the fibrogenic pSmad2L/C pathway, accelerating liver fibrosis and promoting hepatocarcinogenesis."
sparser
"c-Jun N-terminal kinase (JNK) and p38 MAPKs are activated by inflammatory cytokines or environmental stress."
sparser
"One possibility might be that IL-15 but not IL-2 induces another cytokine that can activate JNK and take the relay of IL-15."
sparser
"c-Jun N-terminal kinase (JNK) is activated by oxidants and cytokines and regulates hepatocellular injury and insulin resistance, suggesting that this kinase may mediate the development of steatohepatitis."
Cytokine activates JNK. 1 / 1
1 |
bel
"The 3 members of the JNK group of serine/threonine kinases, JNK-1, -2, and -3, JNK has recently emerged as a central metabolic regulator, playing an important role in the development of insulin resistance in obesity In response to stimuli such as ER stress, cytokines, and fatty acids, JNK is activated, whereupon it associates with and phosphorylates IRS-1 on Ser307, impairing insulin action"