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TNF activates NGF. 10 / 49
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"Similarly, in synovial fibroblasts isolated from patients with osteoarthritis, both IL-1beta and TNFalpha were shown to increase NGF synthesis and release [XREF_BIBR]."
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"TNF stimulates the synthesis and secretion of NGF also in other cells such as human glioblastoma cells."
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"Masuda et al. found that human AF and NP cells constitutively express both NGF protein and mRNA, and the proinflammatory cytokines IL-1beta and TNF-alpha stimulate the production of NGF XREF_BIBR."
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"We have now examined whether the induction of TNF alpha in inflammatory lesions contributes to inflammatory sensory hypersensitivity by inducing IL-1 beta and NGF."
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"Although recent studies suggest that tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta mediate NGF activity in human synovial fibroblasts, the regulation of NGF expression in human synovial macrophages remains unclear."
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"Recent preliminary evidence suggests that the pro inflammatory cytokine tumour necrosis factor alpha (TNFalpha) and growth factor withdrawal can both activate a common apoptotic pathway in nerve growth factor (NGF)-responsive PC12 cells involving caspase 3, albeit through very distinct upstream pathways : the former through active signalling and the latter through passive or lack of survival signalling."
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"In addition, treatment of human cultured CD14 positive and -negative cells with IL-1beta and TNF-alpha enhanced NGF mRNA and protein levels."
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"We have synthesized four kinds of reversed peptides of various physiologically active peptides, which inhibit TNF (tumor necrosis factor) cytotoxicity, produce NGF (nerve growth factor), exert antimicrobial activity and inhibit cell attachment, respectively."
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"We found that 17beta-estradiol promoted NGF production in AM ESCs but not in control ESCs; TNF promoted NGF production in both AM and control ESCs; and CoCl2 inhibited NGF production in control ESCs, but had no effect in AM ESCs."
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"Our results show that the simultaneous addition of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) elicited a marked (13-fold) increase of NGF protein released by cultured rat glomerular mesangial cells within 24 h, whereas IL-1 alpha in combination with TNF-alpha, as well as the cytokines alone, did not promote the synthesis of NGF."