IndraLab

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TIAM1 activates RAC1. 10 / 371
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"To analyze the functional relevance of Tiam1 and Rac1 physical interaction with RORgammat in Th17 cells, we investigated the ability of Tiam1 mediated Rac1 activation to induce the Il17 promoter in reporter assays using 293T cells."
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"Tiam1 is a known activator of Rac1, and we show that Tiam1 promotes endothelial cell size, similar to Trio."
33087700
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"These results indicate that Rac1 was activated mainly by Rac-GEF Tiam1 in SKBR3 cells; Rac1 activation contributed to PTEN deletion- or IGF-IR overexpressing caused Trastuzumab resistance; and inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"One of the logical candidates would be the guanine nucleotide exchange factor, Tiam-1, which was shown to specifically activate Rac1, but not Cdc42 (Sander et al. 1999)."
10725329
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"The signaling mechanism involved recruitment of sphingosine 1-phosphate receptor-1 (S1P-R1) to the caveolin enriched microdomains (CEMs, also known as lipid rafts or caveoli) and activation of serine/threonine kinases mammalian target of rapamycin (mTOR) and phosphoinositide 3-kinase (PI3K) and Rac specific nucleotide exchange factors Tiam1 and Vav2, which stimulated Rac1 GTPase signaling to cytoskeleton and cell junctions."
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"Consequently, increased TIAM1 stability promotes RAC1 mediated tumorigenesis [54 *]."
29723737
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"For example in the Rho subfamily, Tiam1 is a specific activator of Rac1 while Vav promiscuously bind RhoA, RhoG, Rac1, and Cdc42."
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"BDNF-stimulated neuronal morphogenesis is known to require Rac1 activation by Tiam1 ( xref ; xref )."
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"The Rac1-GEFs, Tiam1 and Tiam2, directly interact with Par3 to induce the formation of the Par cell polarity complex [XREF_BIBR], activate Rac1, and promote the formation of neurite outgrowths in N1E-115 cells [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"The above findings have immediate relevance to our current findings for potential involvement of Tiam1 mediated Rac1 activation in GSIS."
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