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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB activates SMAD3. 8 / 604
1 | 7 163 338
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"SB-202190 and SB-203580 deregulate TGFbeta induced Smad3 nuclear accumulation."
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"Recent study demonstrate that TGFβ activate smad3 in medial smooth muscle cells, causing them to secret CTGF, which in turn stimulate adventitial fibroblasts to migrate, proliferate, produce collagen, and transform into myofibroblast [ xref ]."
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"Figure XREF_FIG and Supplementary Fig. 8A show that treatment of NHDF with the selective ERK1/2 inhibitor SCH772984 31 resulted in significantly reduced SMAD3 mRNA level and reduced TGFbeta induced SMAD3 nuclear translocation, when compared to DMSO treated cells."
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"Upon ligand binding by TGF-beta1, type II TGF-beta receptors (TbetaRII) activate type I TGF-beta receptors (TbetaRI), recruiting and activating the intracellular mediators Smad2 and Smad3, which subsequently complex with Smad4 before translocating to the nucleus where the complex regulate gene transcription [XREF_BIBR]."
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"On the contrary, the TGF-β-activated Smad3 triggers strikingly different programs such as mesodermal differentiation in early development."
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"TGF-beta induced the enrichment of Smad3 on the PAI-1 promoter, and this enrichment was abolished by STAT3C (XREF_FIG)."
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"A direct cross talk between the Notch and TGF-beta signaling pathways comes from a recent study in which a direct interaction between Notch intracellular domain and Smad-3 was demonstrated, and activation of Smad-3 by TGF-beta led to an enhancement of Notch induced Hes1 gene transcription."
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"The high TGF-beta expression induced by haemodynamic abnormalities during hyperfiltration may increase production of downstream molecular pathways and further production of Smad3."
TGFB activates phosphorylated SMAD3. 4 / 4
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"Human MRC-5 fibroblasts were incubated for 1 hour with the conditioned media obtained from methacholine stimulated lung slices, followed by analysis of phosphorylated Smad-3, which is specifically activated by TGF-beta."
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"While we have previously described that loss of TGF-beta and Smad3 signaling in Col2a1-Smurf2 transgenic chondrocytes might represent a mechanism of Smurf2 induced OA in Col2a1-Smurf2 transgenic mice, Smurf2 mainly induces ubiquitination of phosphorylated Smad3 activated by exogenous TGF-beta in chondrocytes, and only slightly affects the basal level of phosphorylated Smad3 in resting chondrocytes [XREF_BIBR], indicating that Smurf2 mediated loss of TGF-beta and Smad3 signaling in chondrocytes may not be a dominant mechanism underlying Smurf2 induced OA in Col2a1-Smurf2 transgenic mice."
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"XREF_BIBR We found that treatment of C2C12 cells with recombinant hHGF protein increased the RNA level of miR-206 while decreasing the amount of phosphorylated Smad3 protein induced by TGF-beta, indicating that HGF might counteract the biological consequences generated by TGF-beta."
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"As shown in XREF_FIG, the phosphorylated SMAD3 proteins were induced by TGF-beta and their levels were similar in control cells and JARID2 knockdown cells."
TGFB bound to its activates SMAD3. 1 / 1
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"TGF-beta binding to its receptor triggers the activation of both Smad2 and Smad3."
TGFB activates phosphorylated SMAD3 bound to SMAD4. 1 / 1
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"Here we report that the TGF-beta-activated phospho-Smad3/Smad4 complex utilizes an importin-independent mechanism for nuclear import and engages different nucleoporins for nuclear import compared with the monomeric Smad4."
TGFB bound to TGFBR1 activates SMAD3. 1 / 1
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"TGF-beta binds to a heteromeric complex of transmembrane serine/threonine kinases, the type I and type II receptors ALK5 and TbetaRII, which phosphorylate and activate the TGF-beta-specific intracellular signaling mediators Smad2 and Smad3."
TGFB bound to type II receptor activates SMAD3. 1 / 1
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"TGF-beta binds to the type II receptor, recruits and phosphorylates the type I receptor and subsequently activates its receptor Smad, Smad2 or Smad3, by phosphorylation [XREF_BIBR]."
TGFB bound to type I receptor activates SMAD3. 1 / 1
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"TGF-beta binds to the type II receptor, recruits and phosphorylates the type I receptor and subsequently activates its receptor Smad, Smad2 or Smad3, by phosphorylation [XREF_BIBR]."
TGFB bound to TGFBR2 activates SMAD3. 1 / 1
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"TGF-beta binds to a heteromeric complex of transmembrane serine/threonine kinases, the type I and type II receptors ALK5 and TbetaRII, which phosphorylate and activate the TGF-beta-specific intracellular signaling mediators Smad2 and Smad3."
TGFB activates mutated SMAD3. 1 / 1
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"This analysis also showed that the Smad3 mutant 230-424, which consists of the entire MH2 domain, was as transcriptionally active as wild-type Smad3 and its activity was enhanced further by TGFbeta stimulation."
TGFB activates SMAD3. 1 / 1
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bel
"enforced expression of ARA55 inhibits transforming growth factor-beta-mediated up-regulation of Smad binding element-luciferase reporter activity in NRP-154 and NRP-152 rat prostate and LNCaP human prostate cell lines"