A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

TGFB increases the amount of SMAD2. 10 / 35
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"TGF-beta potently upregulated the expression levels of p-smad2 in both cell lines."
"Furthermore, KLF10 overexpression enhanced the TGFbeta induced Smad2 phosphorylation and increased the transcription of Smad2, but not Smad3 or Smad4 [XREF_BIBR]."
"Tgf-beta stimulation, which curbed sprouting, lead to high pSmad2 levels in all endothelial cells, an effect that was sensitive to the Alk5 inhibitor SB-431542."
"As a positive control, inclusion of exogenous TGF-beta in the cultures dramatically upregulated the levels of P-Smad2, which was positively correlated with the increase in Foxp3 + T cells."
"Furthermore, this effect was specific to the BMP signaling pathway as there was no difference in the levels of phospho-Smad 2 following TGF-beta stimulation (XREF_FIG f)."
"The expression of MADR2, but not of MADR1, was up-regulated by TGFbeta in vitro in a concentration- and time dependent manner."
"In agreement to this finding, TGF-beta could induce pSMAD2 and ZEB1 expression in GG14, whereas in GG16 cells, considerable expression of these proteins could already be detected."
"Loss of Smad3 had essentially no effect on TGFbeta signaling through Smad2, as assessed by western blot analysis of Smad2 phosphorylation, whereas loss of Smad2 caused a slight reduction in the level of Smad3 phosphorylation by TGFbeta."
"Interestingly, nonresponding cells displayed already high levels of pSMAD2 and ZEB1 that could not be suppressed by inhibition of TGF-beta signaling, suggesting the involvement of yet unknown mechanisms."
"Western blotting demonstrated that TGF-beta also enhanced the expression of p-Smad2 in both the active Yap1 group and the Yap1-ko group."
TGFB increases the amount of phosphorylated SMAD2. 1 / 1
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"TGFbeta increased phospho-SMAD2 in both cytosolic and nuclear fractions."
TGFB increases the amount of SMAD2 bound to SMAD3. 1 / 1
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"Furthermore, Cam kinase II blocked nuclear accumulation of a Smad2 and induced Smad2-Smad4 hetero-oligomerization independently of TGF-beta receptor activation, while preventing TGF-beta-dependent Smad2-Smad3 interactions."