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IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TGFB increases the amount of SMAD2. 8 / 35
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"TGF-beta potently upregulated the expression levels of p-smad2 in both cell lines."
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"Furthermore, KLF10 overexpression enhanced the TGFbeta induced Smad2 phosphorylation and increased the transcription of Smad2, but not Smad3 or Smad4 [XREF_BIBR]."
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"Tgf-beta stimulation, which curbed sprouting, lead to high pSmad2 levels in all endothelial cells, an effect that was sensitive to the Alk5 inhibitor SB-431542."
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"As a positive control, inclusion of exogenous TGF-beta in the cultures dramatically upregulated the levels of P-Smad2, which was positively correlated with the increase in Foxp3 + T cells."
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"Furthermore, this effect was specific to the BMP signaling pathway as there was no difference in the levels of phospho-Smad 2 following TGF-beta stimulation (XREF_FIG f)."
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"The expression of MADR2, but not of MADR1, was up-regulated by TGFbeta in vitro in a concentration- and time dependent manner."
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"In agreement to this finding, TGF-beta could induce pSMAD2 and ZEB1 expression in GG14, whereas in GG16 cells, considerable expression of these proteins could already be detected."
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"Loss of Smad3 had essentially no effect on TGFbeta signaling through Smad2, as assessed by western blot analysis of Smad2 phosphorylation, whereas loss of Smad2 caused a slight reduction in the level of Smad3 phosphorylation by TGFbeta."
TGFB increases the amount of phosphorylated SMAD2. 1 / 1
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trips
"TGFbeta increased phospho-SMAD2 in both cytosolic and nuclear fractions."
TGFB increases the amount of SMAD2 bound to SMAD3. 1 / 1
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bel
"Furthermore, Cam kinase II blocked nuclear accumulation of a Smad2 and induced Smad2-Smad4 hetero-oligomerization independently of TGF-beta receptor activation, while preventing TGF-beta-dependent Smad2-Smad3 interactions."