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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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RAS activates ERK. 10 / 1014
| 1 214 769
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"As shown in XREF_FIG, it can be seen that arsenic increased levels of Ras and p-ERK in normal cells indicating that arsenic led to ERK signaling pathway activation."
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"XREF_BIBR As seen in XREF_FIG, the constitutively activated Ras will trigger both the MAPK (RAF/RAS/MEK/ERK) and the PI3K (RAS/PI3K/AKT/mTOR) pathways."
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"The CD44-merlin complex antagonizes Ras-dependent activation of ERK as well as the GTP-loading of Rac [ xref , xref ] ( xref )."
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"Rap1 was previously proposed to modulate the Ras-dependent activation of MAPK in a highly cell type-specific manner( xref )."
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"Ras induces the initial and transient ERK activation on the plasma membrane, whereas Rap1 induces persistent ERK activation in endosomes."
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"Ras-activated MAPK can promote breast tumor cell EMT and metastasis via increasing Twist1 Serine 68 phoshorylation and stabilization[ xref ]."
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"TLR stimulation results in Ras and c-Raf-dependent activation of the MEK and ERK pathway XREF_BIBR."
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"The oncogene Ras activates ERK, and eight of the ten pathways we found to be significant for the Ras gene signature were also found to be significant for the Yang et al. gene signature."
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"The cytoplasmic Grb2 and SOS complex is recruited to the cell membrane, which leads to the activation of Ras mediated MAPK cascade [XREF_BIBR]."
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"Rabex-5-mediated Ubiquitination Attenuates Ras induced ERK Activation."
Mutated RAS activates ERK. 10 / 49
| 49
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"In a majority of human cancers, the PI3K and AKT pathway is frequently activated by the activating mutations of PI3K p110alpha (PIK3CA) and the loss or inactivating mutation of PTEN, whereas hyper activation of MEK and ERK signaling driven by mutant RAS and BRAF is also a common oncogenic event in a variety of cancers [XREF_BIBR, XREF_BIBR]."
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"Papillary and nonpapillary cancers contained similar frequencies of activating RAS mutations (5-10%) [XREF_BIBR], which also function to promote downstream ERK activation."
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"The CAM dependent step in the Erk1/2 activation cascade is downstream of Ras activation, because inhibitors of CAM antagonize Erk1/2 activation induced by constitutively activated mutants of Ras and c-Src but not by constitutively activated mutants of Raf and MEK (mitogen and extracellular signal regulated kinase)."
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"ERK activation was shown to be dependent on the phosphorylation of the MUC1-CT and could be abolished by a dominant negative Ras mutant or by a MEK inhibitor, thus arguing that the MUC1-CT mediates the Grb2-SOS-Ras-MEK-ERK signaling cascade which leads to cell division."
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"MAPK activation induced by the Tpl-2 protein is blocked by dominant negative mutants of Ras and Raf-1, whereas a kinase deficient Tpl-2 mutant down regulates mitogenic signals induced by v-Ha-Ras or v-Raf."
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"This contrasts with observations made in the majority of cell models of Ras transformation, in which ectopic expression of mutant Ras causes persistent ERK activation."
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"However, none of the TKI resistant cell lines showed mutations of the most affected regions of the genes (amino acids 12, 13 and 60 in K-RAS, amino acids 12, 13, and 61 in N-RAS; data not shown), a finding which was scarcely unexpected because RAS mutations would not only stimulate PI3K, but also ERK1/2 in an imatinib-insensitive manner."
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"To validate that ALK and RAS mutations directly activate the RAS and MAPK pathway in neuroblastoma cells, we inducibly expressed an ALK F1174L and an NRAS v61Q mutation in two cell lines that did not harbor RAS MAPK mutations."
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"Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y."
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"Ras mutations activate the MAPK and PI3K-Akt signaling pathways in thyroid tumorigenesis [XREF_BIBR]."
GTP-bound active RAS activates ERK. 8 / 8
1 7 |
bel
"Thus, altogether these results suggest that, although Ras may be involved in the initial phase of ERK activation by TPO, other pathways are required to maintain ERK activation for prolonged periods"
bel
"3CH134 protein, and the protein synthesis inhibitor cycloheximide leads to persistent activation of MAP kinase. 3CH134 blocks phosphorylation and activation of p42MAPK mediated by serum, oncogenic Ras, or activated Raf"
bel
"Ras is involved in CpG ODN signaling as an early event by associating with TLR9 and promoting IRAK1/TRAF6 complex formation, and MAPK and NF-kappaB activation."
bel
"Lysophosphatidic acid (LPA) is the prototypic G-protein-coupled receptor agonist that activates the Ras-mitogen-activated protein (MAP) kinase cascade"
bel
"In the presence of an inhibitor of farnesly transferase (Ftase-1), which prevent the maturation of Ras, both Estradiol and TGF alpha induced ERK activation was significantly inhibited."
bel
"stimulation of Erk by alpha6beta4 was suppressed by dominant-negative Shc, Ras and RhoA"
bel
"Figure 5. This is a figure in the review representing the cross talk between FGFR3 and IL6 signaling in multiple myeloma cell line KH11; the legend is as follows: Fig. 5. Enhanced proliferation of myeloma cells by interleu- kin- 6 cooperatingwith FGFR3-mediated signals. IL- 6 and FGF induce the distinct intracellular signaling pathways in myeloma cells carryingt(4 ;14)(p16. 3 ;q32) that ectopically express FGFR3. FGF and IL- 6 activate ERK1/ 2, PI- 3 kinase and STAT3, respectively. The serine phosphorylation of STAT3 via the FGF- induced ERK1/ 2 activation contributes to the full activation of STAT3, leadingto the expression of c-myc and bcl- 2 genes and cell proliferation 91 .FRS:FGF receptor substrate."
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"p38 MAPK is activated in a ERK-dependent fashion, thus indicating that Ras promotes premature senescence by sequentially activating the ERK and p38 MAPK pathway [68]."
RAS activates phosphorylated ERK. 6 / 6
| 6
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"Both MAPK and PI3K-AKT signaling pathways are downstream of Ras, since inhibition of Ras abolishes the circadian rhythm of pERK and pAKT, while inhibition of cAMP signaling dampens the circadian rhythm of Ras activity."
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"Together, these data support a signal transduction pathway during in vitro conditioning in which PKCzeta activates MEK directly or through Ras and Raf to potentiate the function of p-ERK."
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"In contrast, depletion of the WT Ras isoforms increased pERK in MIA PaCa-2 and RD cells, suggesting that WT Ras may antagonize mutant Ras and ERK signaling."
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"Although overexpression of ERRB2 led to increased metastatic potentials in PC3 cells and DU145 cells, overexpression of H-RAS did not have similar effects on these two cell lines or the LnCaP cell line (XREF_FIG and XREF_FIG), despite the fact that RAS overexpression did elevate p-ERK (particularly p-ERK1) as well as p-AKT and/or p-p38 in all of the three human prostate cancer cell lines (XREF_FIG)."
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"These findings were further confirmed in IF studies in which the presence of active Ras restored pERK accumulation in the nucleus of DU145-Sef cells (XREF_FIG)."
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"As expected, both PIK3CA and RAS increased phospho-AKT (pAKT S473) and phospho-S6 (pS6) levels, and RAS increased phospho-ERK (pERK) with limited variations in the levels of S6, AKT, and ERK proteins."
RAS-V12 activates ERK. 5 / 5
| 5
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"PME-1 depletion inhibited ERK pathway activity induced by RasV12, whereas cells expressing constitutively active alleles of either B-Raf or MEK, were found resistant to PME-1 shRNA (XREF_FIG, XREF_FIG)."
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"Mechanism study showed that PDHB inhibited ERK signaling and cell growth driven by RasV12."
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"However, alpha3beta1 was not required for RasV12 mediated activation of ERK or for ERK dependent MMP-9 promoter activity."
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"RanBPM was found to inhibit MEK and ERK activation induced by ectopic expression of active RasV12."
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"It has been shown that the oncogenic Ras mutant, RasV12, activates ERK1/2 strongly, and that the constitutively active MEK5 mutant, MEK5D, selectively activates ERK5 XREF_BIBR, XREF_BIBR."
RAS bound to GTP activates ERK. 4 / 4
| 4
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"Mutant RAS-GTP enhances BRAF V600E dimerization, reactivates the ERK pathway and confers resistance to BRAF inhibitors since these drugs only block monomeric BRAF V600E [XREF_BIBR]."
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"Early experiments using the immortalized Jurkat T cell line showed that overexpression of DGKzeta inhibits TCR signaling by reducing the levels of active GTP bound Ras and, consequently, diminishing ERK activation."
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"Activated RAS (RAS-GTP) can stimulate the MAPK pathway by activating the RAF protein kinases."
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"A possible explanation of this phenomenon is that BRAF inhibitor binding activates wild-type RAF isoforms by inducing dimerization, membrane localization and interaction with RAS-GTP, which ultimately activates the MAPK pathway [XREF_BIBR]."
RAS bound to RAF activates ERK. 2 / 2
| 2
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"In its GTP bound state, Ras can bind Raf and activate a MAPK cascade that includes MEK and Erk."
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"Ras binds to and activates Raf and initiates activation of MAPK signaling cascade."
Active RAS activates ERK. 1 / 1
| 1
trips
"Moreover, Erbin inhibits the Erk activation by active Ras, while it fails to do so in the presence of active Raf-1."
RAS bound to EGFR activates ERK. 1 / 1
| 1
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"We have demonstrated that transactivation includes a positive feedback circuit that connects proteolytic release of autocrine TGFalpha to EGFR binding to Ras mediated ERK signaling, and that the activity of this circuit can be regulated at different points by diverse inputs."
RAS-G12V activates ERK. 1 / 1
| 1
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"Analysis of downstream signaling showed no impact of ErbB3 depletion on the Ras G12V -dependent activation of Erk and Akt (XREF_SUPPLEMENTARY)."
RAS bound to SOS1 activates ERK. 1 / 1
| 1
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"The canonical model of Grb2 function relies on the widely confirmed observation that Grb2 is constitutively associated with Son of sevenless (SOS) and upon growth factor activation and tyrosyl phosphorylation, Grb2 brings Sos1 into close proximity of membrane bound Ras, thereby activating Ras and the downstream MAPK cascade [XREF_BIBR]."
RAS-N116Y activates ERK. 1 / 1
| 1
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"Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y."
Mutated RAS activates phosphorylated ERK. 1 / 1
| 1
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"A second key finding was that depletion of mutant Ras increased signaling (pERK and pAKT) through the EGF receptor (EGFR)."
RAS bound to RAF1 activates ERK. 1 / 1
| 1
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"Initially, Ras interacts with and activates Raf-1, which in turn activates MAPK and ERK kinase (MEK) -1 and -2 by serine phosphorylation."
RAS bound to WB activates ERK. 1 / 1
| 1
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"We also show that WB binds to Ras and Raf to activate the downstream MAPK pathway to exert its effects."
RAS-R68Q activates ERK. 1 / 1
| 1
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"Perhaps the enhanced signaling activity of Ras R68Q is able to activate the MAPK effector branch, but does not reach a required threshold to engage the PI3-K and Akt-kinase pathway XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
RAS-L61Q activates ERK. 1 / 1
| 1
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"To determine if the effects of PP2 and U0126 were due to direct action on Sam68, we coexpressed the SFK Fyn or a constitutively active form of RAS (RAS L61Q), which stimulates the ERK1/2 pathway, with suboptimal amounts of Sam68 and determined the effect on the cyclin D1 minigene AS."