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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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RAS increases the amount of TP53. 6 / 8
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"It should be noted that the induction of p19 Arf and p53 protein levels in Skp2 -/- MEFs by Ras was comparable if not lower than that of wild-type MEFs (XREF_SUPPLEMENTARY)."
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"Thus, we identify a mechanism by which Ras and NORE1A can modulate p53 protein levels."
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"Although oncogenic Ras may increase p53 levels, it is not clear whether this increase is sufficient to explain the induction of senescence."
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"RAS induces p53 expression in the absence of p19ARF."
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"We have recently found that the Ras effector and RASSF (Ras Association Domain Family) family member RASSF5 and NORE1A enhances the levels of nuclear p53."
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"Down-regulation of RPL23 significantly attenuated RAS induced p53 expression in p19Arf -/- MEFs (XREF_FIG) as well as in Mdm2 m/m; p19Arf -/- compound MEFs (XREF_FIG), suggesting that in the absence of p19ARF, RPL23 is a major mediator of p53 expression induced by oncogenic RAS."
RAS-V12 increases the amount of TP53. 6 / 6
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"Further, while RasV12 induced the expression of Cdc6 and p53, IKKbetaca, acting together with RasV12, suppressed their expression to levels similar to those detected in IMR-90 IKKbetaca cells; and Cdc6 expression levels in IMR-90 IKKbetaca cells appeared to be comparable to their empty vector controls (XREF_FIG)."
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"RasV12 failed to induce p53, p19ARF, p16INK4a, and p15INK4b expression in KSR1-/- MEFs and increased proliferation instead of causing growth arrest."
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"Thus, while RasV12 induced the expression of the p53 - p21 Cip1 and Waf1 axis, IKKbetaca only contributed to p21 Cip1 and Waf1 induction, which has been reported to be a target of activated canonical NF-kappaB in other cells."
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"Analysis of cell cycle regulatory proteins in confluent cells showed that overexpression of RasV12 induced the expression of cyclin D1 and Cdc6 but also of p53 and its target protein p21 Cip1 and Waf1."
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"Similarly, overexpression of RasV12 induced the expression of p53 and also triggered its stabilizing phosphorylations at Ser15 and Ser20."
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"Importantly, enforced expression of IKKbetaca suppressed both the basal and RasV12 induced expression levels of p53 in IMR-90 fibroblasts (XREF_FIG)."
Modified RAS increases the amount of TP53. 3 / 3
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"We found that over-expression of ras in normal haemocytes did not lead to a higher expression of p53 or Mdm as found in vertebrates."
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"RAS can activate mRNA transcription and translation of Mdm2 and p53, as well as induce ARF, a tumor-suppressor protein that binds MDM2 and blocks MDM2 mediated p53 degradation in a cell-type dependent manner."
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"Conversely, continuous overexpression of oncogenic Ras and its various effectors can lead to irreversible cell cycle arrest by upregulating the levels of p16 Ink4a, p19 Arf, and p53."
GTP-bound active RAS increases the amount of TP53. 1 / 1
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"The constitutive activation of Ras provokes premature senescence in vascular cells, which is associated with accumulation of the proteins p53 as well as p16 [20]."