IndraLab

Statements

PTK6 phosphorylates SMAD4. 5 / 5
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"Our search for signaling pathways regulated by breast tumor kinase (BRK), a nonreceptor protein tyrosine kinase that is up-regulated in ~80% of invasive ductal breast tumors, led us to find that BRK competitively binds and phosphorylates SMAD4 and regulates transforming growth factor-β/SMAD4 signaling pathway."
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"A constitutively active BRK (BRK-Y447F) phosphorylates SMAD4, resulting in its recognition by the ubiquitin-proteasome system, which accelerates SMAD4 degradation."
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"BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential."
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"A constitutively active BRK (BRK-Y447F) phosphorylates SMAD4, resulting in its recognition by the ubiquitin-proteasome system, which accelerates SMAD4 degradation."
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"Importantly, BRK 's phosphorylation of SMAD4 targets it for ubiquitination and degradation, which in turn leads to a repression of its downstream target, the tumor suppressor fyn related kinase (FRK), which is involved in EMT processes."
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