"Notch drives differentiation of Schwann cell precursors."
"However, Notch alone is unable to trigger differentiation of progenitors into vSMC, indicating the presence of an elaborate hierarchy of operative transcription factors."
"Moreover, Notch signaling induces cell cycle re-entry of immature cardiomyocytes, promotes proliferation and myogenic differentiation of CPCs, decreases oxidative and nitrosative stress and prevents cardiac fibrosis."
"Previous studies documented that arterial differentiation is impaired by inhibition of multiple Notch signaling pathways (for instance by a dominant negative Su (H)), 7 but not by selective silencing of Dll4 XREF_BIBR, XREF_BIBR."
"In the present study, we investigated the role of Notch signaling in the BMP9 induced osteogenic differentiation of MSCs."
"Available data provide a consensus view on the critically important role of Notch signaling in myeloid cell differentiation."
"In neural stem cells, targets of Notch signalling work together to prevent terminal differentiation and preserve a pool of stem cells [XREF_BIBR, XREF_BIBR]; Notch1 also promotes radial glia like identity and negatively regulates cell cycle exit and neuronal differentiation in GFAP-NSCs in the postnatal brain [XREF_BIBR]."
"Our FCM data revealed that Notch enhanced the proliferation of MSCs by decreasing the percentage of cells in the G0/G1 phase, and increasing the percentage of cells in the S phase In conclusion, we demonstrated that Notch signaling can potentiate the BMP9 induced osteogenic differentiation of MSCs."
"These experiments demonstrated that Notch signaling activation is able to induce differentiation of the AML leukemia initiating population toward the macrophage and/or DC lineages, eventually leading to cell death and disease regression in vivo."
"However, we confirm the role of Notch signaling in nematocyte differentiation and tentacle morphogenesis."