IndraLab

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NGF activates NTRK1. 10 / 841
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"NGF activated TrkA is primarily (~ 70%) recycled to the plasma membrane after endocytosis in PC12 cells, whereas most EGF activated EGFR (~ 80%) is targeted for lysosomal degradation in parallel studies."
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"Treatment with a mutant NGF that only activates TrkA affords significant neuroprotection."
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"As the activation of TrkA by NGF regulates the levels of PIP2 by the activation of the PI3K and PLCγ pathways ( xref ), we further study the disruption of p75-CTF oligomerization by the use of different TrkA mutants ( xref )."
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"In PC12 cells, activation of TrkA by NGF induces the proteolytic processing of p75 NTR, resulting in the accumulation of the p75 NTR CTF and also its ICD [XREF_BIBR]."
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"p75 induces the neurotrophin NGF mediated survival in neuronal cells expressing TrkA."
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"TrkA is mainly triggered by NGF, 135 and TrkB is more inclined to brain‐derived neurotrophic factor."
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"Trk neurotrophin receptors, TrkA (encoded by the NTRK1 gene), TrkB (encoded by NTRK2), and TrkC (encoded by NTRK3) are activated primarily by their endogenous ligands, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3), respectively."
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"Our findings are also not at odds with the observation of Woo and colleagues, who demonstrated that NGF promotes dimerization of the soluble extracellular domain of TrkA (Woo et al., 1998)."
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"APP regulates NGF mediated TrkA activation and the sensitivity of neurons to the trophic action of NGF."
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"PI3K binds to TRPV1 directly via its p85α subunit, which presumably recognizes the phosphorylated Y200 of TRPV1, to enhance TRPV1 surface trafficking upon NGF stimulation of TrkA in DRG neurons [78]."
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NGF bound to NTRK1 activates NTRK1. 9 / 9
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"In addition, the NGF induced REM sleep like state is mediated by tropomyosin related kinase A (trkA) which binds with high affinity to NGF and, to a lesser extent, to neurotrophin-3."
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"NGF binding to TrkA causes TrkA dimerization, followed by autophosphorylation of multiple tyrosine residues located within the intracellular domain of TrkA."
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"To exert its effects, NGF selectively binds to its high affinity TrkA receptors, located at the plasma membrane of responsive cells, which causes TrkA receptors to form homodimers and activates the intrinsic tyrosine kinase activity of the receptor resulting in autophosphorylation of receptor subunits."
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"NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20]."
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NGF binding to TrkA upregulates TrkA receptors (Kumar and Mahal, 2012), glutamatergic receptors (Pezet and McMahon, 2006), and substance P/CGRP through the PKCε pathway (Kallakuri et al., 2004; Kobayashi et al., 2004; Kumar and Mahal, 2012)."
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"As we demonstrated that hfNBMs express the TrkA receptor, we next questioned whether the formation of a NGF and TrkA complex activated a functional TrkA signaling pathway and assessed the phosphorylation of TrkA (pTrkA) and the activation of TrkA down-stream effectors (p-ERK1/2, p-CREB or c-fos)."
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"NGF binding to TrkA activates the tyrosine kinase domain of TrkA, which triggers pathways involving ERK1/2, Akt, and PLCγ (Chao et al. 2006)."
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"NGF binds to TrkA, activates the intrinsic kinase activity of TrkA, and promotes the differentiation of pheochromocytoma (PC12) cells into sympathetic like neurons."
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Mutated NGF activates NTRK1. 3 / 3
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"During retinal degeneration due to glaucoma or optic nerve transection, treatment with a mutant NGF that only activates TrkA, or with a biological response modifier that prevents endogenous NGF and pro NGF from binding to p75 (NTR) affords significant neuroprotection."
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"Our data helps to explain the molecular mechanisms involved in TrkA downstream activation mediated by WT and mutant NGF, providing new insights to novel development to trigger each signaling pathway specifically."
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"Treatment with a mutant NGF that only activates TrkA affords significant neuroprotection."
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NGF activates NTRK1. 2 / 2
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"Neurotrophins signal via Trk tyrosine kinase receptors. Nerve growth factor (NGF) is the cognate ligand for TrkA, the brain-derived neurotrophic factor for TrkB, and NT-3 for TrkC. NT-3 also binds TrkA as a lower affinity heterologous ligand."
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"Additionally, NGF stimulated the expression of VEGF isoforms in cancer explants. The effect was dose-dependent and inhibited by a NGF antibody and by K(252a), a trk receptor inhibitor."
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NGF bound to its activates NTRK1. 2 / 2
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"Specifically, the binding of NGF to its receptors promotes the formation of trkA homodimers and trkA-p75 NTR heterodimers and the autophosphorylation of the receptors, which then activate downstream signalling cascades such as mitogen activated protein kinases (MAPK), also known as extracellular signal regulated kinases (ERKs), and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (PKB, also known as AKT), resulting in enhanced neuronal survival and growth."
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"The NGF binding to its receptor potentiates an unprecedented GPCR signaling via membrane Galphai subunit proteins and MMP-9 activation to induce the activation of Neu1 sialidase in live primary neurons and TrkA- and TrkB expressing cell lines, as depicted in XREF_FIG."
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NGF bound to NT-4/5 activates NTRK1. 1 / 1
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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NGF activates NTRK1-F592A. 1 / 1
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"Nanomolar concentrations of either 1NMPP1 or 1NaPP1, derivatives of the general kinase inhibitor PP1, inhibit NGF and BDNF signaling in TrkA (F592A) and TrkB (F616A) neurons, respectively, while no such Trk inhibition is observed in wild-type neurons."
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Mutated NGF activates mutated NTRK1. 1 / 1
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"The two best understood syndromes are Hereditary Sensory and Autonomic type 4 (HSAN-IV) caused by NTRK1 mutations and HSAN-V caused by NGFB mutations ."
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NGF bound to TrkA receptor activates NTRK1. 1 / 1
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"Tagliabue et al. [26] have found that in breast cancer cells expressing low levels of TrkA, NGF binding to the TrkA receptor stimulates pl85 HER2 signaling to induce cell growth probably by recruiting[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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NGF bound to HCLS1 activates NTRK1. 1 / 1
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"These data provide evidence for an NGF inducible interaction of TrkA homodimers, but not TrkA and p75 heterodimers.Several reports have shown that NGF binding to p75 initiates an apoptotic cascade in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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NGF-R100W activates NTRK1. 1 / 1
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"Intraplantar injection of NGF R100W into adult rats induced neither TrkA mediated thermal nor mechanical acute hyperalgesia, but retained the ability to induce chronic hyperalgesia based on agonism for TrkA signaling."
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NGF bound to BDNF activates NTRK1. 1 / 1
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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NGF bound to TrkA receptors activates NTRK1. 1 / 1
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"To exert its effects, NGF selectively binds to its high affinity TrkA receptors, located at the plasma membrane of responsive cells, which causes TrkA receptors to form homodimers and activates the intrinsic tyrosine kinase activity of the receptor resulting in autophosphorylation of receptor subunits."
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NGF bound to NTRK2 activates NTRK1. 1 / 1
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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NGF bound to NGFR activates NTRK1. 1 / 1
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"Pro-NGF can bind p75NTR with a high affinity and activate trkA, too [40,41]."
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NGF bound to NTF3 activates NTRK1. 1 / 1
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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NGF bound to NTRK3 activates NTRK1. 1 / 1
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"The Trks exhibit some selectivity in their preference for neurotrophin binding - NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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