IndraLab

Statements

MTOR phosphorylates EIF4EBP1. 10 / 806
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"MTOR kinase inhibitors have been shown to suppress phosphorylation of 4E-BP1 and global translation more effectively than rapalogs [XREF_BIBR, XREF_BIBR]."
24623675
reach
"This suggested the possibility that the phosphorylation of 4E-BP1 by mTOR immunoprecipitates was due to the presence of an associated kinase which was released from the immunoprecipitate in the presen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10471835
reach
"Dissociation of the eukaryotic initiation factor-4E/4E and BP1 complex involves phosphorylation of 4E-BP1 by an mTOR associated kinase."
10471835
rlimsp
"Another exogenous substrate phosphorylated by immunopurified mTOR in vitro is eIF4E-binding protein 1 (4E-BP1) at sites corresponding to those phosphorylated in vivo during insulin stimulation in a Ser/Thr-Pro motif."
14560963
sparser
"MTOR phosphorylates 4EBP1–3, which inhibits their activity and consequently allows release of eIF4E to promote cap-dependent translation."
23421405
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"This suggests that Akt mediates mTOR dependent phosphorylation of 4EBP-1 and S6K in VHL deficient cells."
20304964
sparser
"Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1."
9561852
reach
"DDIT4L inhibits mTOR-mediated phosphorylation of 4E-BP1."
34599932
rlimsp
"Eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) - a key mTOR substrate, binds and sequesters eIF4E to impede translation initiation that is supposedly overcome upon 4E-BP1 phosphorylation by mTOR."
24975846
reach
"MTOR phosphorylates p70 S6 kinase (p70S6K) and the 4E-BP1 translational repressor, leading to translation of proteins required for cell proliferation."
19690197