A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

MEK increases the amount of SERPINE1. 5 / 5
| 5
reach
"Differential MEK and ERK involvement in colchicine induced PAI-1 and CTGF expression."
reach
"The TNF-alpha induced expression of PAI-1 mRNA was not affected by PD98059, an inhibitor of MEK, SB203580, an inhibitor of p38 MAPK, nor LY294002, an inhibitor of PI3 K. However, DMAP, an inhibitor of SAPK and JNK, inhibited the expression of PAI-1 mRNA, suggesting that the TNF-alpha induced expression of PAI-1 mRNA is regulated by the SAPK and JNK dependent pathway in human mesangial cells."
reach
"Pharmacologic inhibition of keratinocyte MEK signaling effectively ablated scrape induced PAI-1 mRNA expression but failed to attenuate wound associated increases in cellular PAI-1 protein levels soon after monolayer injury."
reach
"The recent identification of USF/ERK1/2 complexes and the requirement for MEK signaling in TGF-beta1-dependent ERK1/2 activation and PAI-1 transcription suggests a possible functional interaction between USF and one or more MAP kinases."
reach
"Accordingly, the inhibition of MEK1/2 and Rho-kinase, two downstream signaling cascades activated by S1P 2, blocked the activation of PAI-1 and uPAR mRNA expression by S1P."
Kinase-active MEK increases the amount of SERPINE1. 1 / 1
1 |
bel
"the MEK (ERK kinase) inhibitors, PD98059 and UO126, completely prevented PAI-1 induction by Wy-14,643"