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JNK activates SMAD3. 10 / 15
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"However, JNK can also activate the M2 phenotype transcription factor SMAD3 [XREF_BIBR]."
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"JNK pathway mediates TGFβ-induced EMT in keratinocytes. xref Further it was shown that activation of Smad3 by JNK is necessary to mediate TGFβ -induced EMT. xref "
22572828
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"P38 MAPK and c-Jun N-terminal kinase (JNK) can activate Smad 3 [ xref , xref ] and p38 MAPK also strengthens interaction between Smad3 and coactivators [ xref ]."
19961576
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"P38 MAPK and c-Jun N-terminal kinase (JNK) can activate Smad 3 [XREF_BIBR, XREF_BIBR] and p38 MAPK also strengthens interaction between Smad3 and coactivators [XREF_BIBR]."
19961576
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"In this study, we found that blockade of KCa3.1 inhibited the activation of Smad2, Smad3 and Erk1/2 signaling pathways, but not p38 and JNK MAPK pathways, indicating that KCa3.1 plays an important role involving Smad2, Smad3 and ERK1/2 in kidney myofibroblast activation by TGF-beta1."
24166472
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"Furthermore, ERS and JNK pathway inhibition decreased the expression levels of TGF-beta and Smad3 pathway signals in cells incubated with TM."
31180530
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"Smad3 itself is activated by phosphorylation at the C-terminus (pSmad3C) or at the linker domain (pSmad3L) through TGF-beta type I receptor or TGF-beta-dependent c-Jun N-terminal kinase."
33746950
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"In addition, this pathway can be deregulated in the context of active RAS signaling, through JNK mediated SMAD3 signaling [XREF_BIBR]."
28587062
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"Furthermore, IFNgamma reduced JNK phosphorylation, which tightly was associated with decreased phosphorylation of downstream factors c-Jun and Smad3 and decreased binding activity of c-Jun and Smad3 in the preprpET-1 promoter."
22301113
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"This finding supports the postulate that JNK mediated Smad3 linker region phosphorylation is an important mechanism by which reduced eNOS expression promotes renal fibrosis."
24391884
Kinase-active JNK activates SMAD3. 1 / 1
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"c-Jun NH(2)-terminal kinase tended to induce the phosphorylation of Smad2/3L in human colorectal adenoma-carcinoma sequence (phosphorylation increases formation of SMAD234 complex)"
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