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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGFR leads to the phosphorylation of SRC. 10 / 42
| 5 16 21
reach
"Unlike EGF activated EGFR, CS stimulated EGFR triggers aberrant Src phosphorylation in lung cancer cells."
sparser
"Abolition of SRC kinases-mediated EGFR phosphorylation has been shown to inhibit EGF-induced proliferation and/or transformation in many types of cancer cells, such as breast cancer cells and cervical cancer cells [ xref , xref ]."
reach
"Mechanistically, de4 EGFR significantly upregulated the extracellular regulated protein kinase, AKT, focal adhesion kinase (FAK) and Src phosphorylation and matrix metalloproteinase-9 expression while downregulated the expression of E-cadherin."
sparser
"NT also induced a time-dependent increase in EGFR Tyr(845) phosphorylation and phosphorylation of c-Src and signal transducer and activator of transcription 5b (Stat5b) (a downstream effector of Tyr(845)), events that were blocked by specific inhibition of c-Src (which mediates Tyr(845) phosphorylation of EGFR) or of EGFR."
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"VAV1 was activated by Src dependent phosphorylation, which in turn was activated by EGFR, and led to activation of a Rac-Pak-NF-kappaB signalling pathway and cyclin D1 upregulation."
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"In addition, C-ANP 4-23 treatment also attenuated the enhanced expression of AT1 receptor, Gqalpha, PLCbeta1, Nox4, and p47 phox proteins, the enhanced activation of EGFR, PDGFR, IGF-1R, enhanced phosphorylation of ERK1/2/AKT and c-Src in VSMC from SHR."
sparser
"They inhibit the phosphorylation of the peptide substrate RR-Src by the EGF receptor purified from ER 22 cells, with IC50 values in the range 0.02-0.45 microns."
rlimsp
"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site [58]."
rlimsp
"Starting with 5-S-glutathionyl-beta-alanyl-L-dopa (1) and 5-S-glutathionyl-beta-alanyl-dopamine (2), a series of analogues with truncated glutathionyl and beta-alanyl-dopa moieties were synthesized, and their inhibitory effects on autophosphorylation and substrate phosphorylation reaction by c-Src and by epidermal growth factor receptor (EGFR) were evaluated."
sparser
"For the first time, we demonstrated that stimulation of the GAGA A R leads to EGFR signaling activation, including elevated expression of EGFR ligands, trans -phosphorytion of the EGFR, and tyrosyl p[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
EGFR phosphorylates SRC on Y419. 8 / 8
| 2 1 5
rlimsp
"However, when the EGFR is continuously activated (Figure 3C), it might phosphorylate Src at Y416 position to activate the downstream signaling pathway."
reach
"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
sparser
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context xref ."
reach
"The dependency of O 3 -induced EGFR activation on Src activation in HBEC is supported by the findings of O 3 -induced phosphorylation of Src at Y416, the phosphorylation of EGFR at the transactivation site Y845, and the inhibitory effect of Src kinase inhibitors on EGFR phosphorylation."
rlimsp
"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context [58]."
reach
"Src was not found to be involved in the EGFR activation as indicated by unchanged phosphorylation of Src Tyr 416 and EGFR Tyr 845."
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"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site XREF_BIBR."
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"It is previously known that EGFR can phosphorylate Src at Y416 site, whereas activated Src can phosphorylate EGFR at Y845 site in a defined cellular context XREF_BIBR."
EGFR phosphorylates SRC on tyrosine. 3 / 3
| 3
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"We also review the complex regulation by tyrosine phosphorylation by epidermal growth factor receptor (EGF-R), Janus Kinase 3 (JAK3) and Src and the role of phosphatases."
reach
"The activated EGFR signals through phosphorylated tyrosine residues to stimulate multiple pathways, including mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, signal transducers and activators of transcription (STAT), phospholipase C, and Src and focal adhesion kinase (Src and FAK) pathways."
reach
"We also present the complex regulation by tyrosine phosphorylation by epidermal growth factor receptor (EGF-R), Janus Kinase 3 (JAK3) and Src and the role of phosphatases."
EGFR phosphorylates SRC on Y216. 1 / 1
| 1
rlimsp
"In addition, ZD1839 suppressed EGF-induced stimulation of EGFR autophosphorylation on Y1086 and Grb2-binding Y1068 sites, c-Src phosphorylation on Y215, and Pak1 activity."
EGFR phosphorylates SRC on P38. 1 / 1
| 1
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"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
EGFR leads to the phosphorylation of SRC. 1 / 1
| 1
reach
"EGFRvIII increased SFK phosphorylation in U87MG cells and sensitized them to dasatinib in matrigel migration assays (XREF_FIG)."
EGFR phosphorylates SRC at position 2. 1 / 1
| 1
reach
"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
Kinase-active EGFR leads to the phosphorylation of SRC. 1 / 1
1 |
bel
"The EGFR-dependent NSCLC cell lines HCC827 and H3255 had increased phosphorylation of SFKs, and treatment of these cells with an SFK inhibitor (PP1 or SKI-606) induced apoptosis."
EGFR phosphorylates SRC on Y418. 1 / 1
| 1
rlimsp
"Consistent with previous studies252627, we observed that EGFR autophosphorylation at Tyr1173, Src phosphorylation at Tyr418, tyrosine phosphorylation of β4 integrin, and FAK autophosphorylation at Tyr397 were more prevalent in MDA-MB-231 cells compared to MCF7 cells (Figs 1a and 2a), implying that a tyrosine phosphorylation cascade through EGF/Src-family kinases (SFKs) is associated with β4 integrin/FAK complex formation."