IndraLab

Statements

Bortezomib decreases the amount of BCL2. 10 / 30
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bel
"From table 1 of full text: bortezomib suppressed constitutive NF-kappaB activation via I-kappaB stabilisation in three ATL cell lines (TaY, MT-2 and MT-4). An oligonucleotide DNA microarray analysis of TaY cells revealed upregulation of genes encoding heat shock proteins (HSPA1A, STIP1, HSPA1B, and HSPCA), genes related to protein folding (CDC37 and ANAPC5), Fas-associated factor 1(FAF1) and an oxidative stress-related gene, heme oxygenase-1(HMOX-1), known to be a target gene of hypoxia-inducible gene-1 alpha (HIF-1 alpha)."
17895889
reach
"Western blot analysis demonstrated that bortezomib treatment significantly decreased the expression levels of Bcl-2 (XREF_FIG) and LC3-II (XREF_FIG), and increased the expression levels of p62, cleaved PARP and cleaved caspase-3 (XREF_FIG) in shBeclin-1 NB4 cells compared with in shCTRL cells."
33376542
ctd
No evidence text available
24377552
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15781649
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20383943
ctd
No evidence text available
17351739
ctd
No evidence text available
18928586
ctd
No evidence text available
21302442
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"MSC-exo inhibits the reduction of Bcl-2 expression caused by bortezomib and reduces the cleavage of caspase-9, caspase-3, and PARP."
33294586
reach
"In this model, in cells expressing p50 NFkappaB, the Bcl-2 promoter would be occupied predominantly by p50/50 homodimers, which would not regulate Bcl-2 transcription, and thus Bcl-2 expression would not be suppressed by the bortezomib induced nuclear IkappaBalpha."
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