IndraLab
Statements
"As shown in Figure 2A, in the absence of doxycycline, both Tyr15-phosphorylated cdk2 and cdk1 accumulate in response to cisplatin treatment. After depletion of cdk2, Tyr15 phosphorylation of cdk1 increased to the same degree as in cells in which cdk2 levels were intact (Figure 2A, left-hand panel). However, in the absence of cdk1, phosphorylation of cdk2 at Tyr15 was compromised, indicating cdk2 activity was not reduced after DNA damage treatment (Figure 2A, righthand panel)."