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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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Lipopolysaccharide activates JNK. 9 / 468
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"First, LPS activates not only ERK, but also JNK and p38 in Kupffer cells 30."
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"LPS has been shown to induce JNK and p38 activation [XREF_BIBR]."
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"AMPK activation by AICAR or metformin attenuates either AngII- or lipopolysaccharide induced oxidative endothelium injury, and c-Jun N-terminal kinase (JNK) activation, via mitochondrion stabilization and increased mitochondrial biogenesis by PGC-1alpha [XREF_BIBR]."
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"Next, we further tested whether super-low-dose LPS mediated JNK activation may be responsible for the disruption of Smad4 and IRAK-M."
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"In this study, we demonstrated that administration of LPS and D-GalN initiated the activation of ERK, JNK, and p38 MAPK."
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"Here, we showed that activation of JNK by LPS contributes to a reduction of Cx43 expression and GJIC in astrocytes via ubiquitin-proteasome pathway, suggesting that inhibition of JNK signaling cascades may provide therapeutic benefit in the development of CNS disorders."
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"Microglial LRP1 was also essential for EP to suppress JNK activation induced by lipopolysaccharide."
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"CO activated several stress kinase pathways, while LPS induced JNK activation was delayed and NF-kappaB signaling was impaired."
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"Mechanistically, we demonstrate that LPS activated JNK and PI3K signaling pathways are involved in suppressing Pdcd4 expression and resultant TNF-alpha production in macrophages (XREF_FIG and XREF_FIG)."
Lipopolysaccharide activates JNK. 4 / 4
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"Treatment with LPS resulted in significant increases in ERK, JNK, and p38 phosphorylation compared with control, and these events were not inhibited by cotreatment with lutein (Fig. 4D)."
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"It is known that LPS stimulation leads to increased activation of three subgroups of MAPKs, i.e., ERK, JNK, and p38, in murine macrophages and human monocytes (38, 39)."
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"In addition, activation of JNK and p38 was reduced in lipopolysaccharide (LPS)-stimulated IRAK-4 KD macrophages."
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"The phosphorylation of MAPKs including ERK1/2, p38, and JNK was measured by immunoblot analysis using specific Abs. LPS-induced phosphorylation of ERK1/2, p38, and JNK was inhibited by EGCG (Fig. 4A?C). However, in 67LR-ablated cells, the inhibitory effect of EGCG on LPSinduced upregulation of phosphorylation was attenuated (Fig. 4A?C)."
Lipopolysaccharide bound to TLR4 activates JNK. 3 / 3
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"Studies in non hepatic cells suggest that LPS binding to toll like receptor 4 protein (TLR4) results in the activation of the transcription factor, NF-kappaB and the stress activated kinases, JNK and p38 MAPK."
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"For example, LPS binds to TLR4 mediated by myeloid differentiation primary response protein 88 (MyD88), and activates c-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NFkappaB), two important inflammatory signaling molecules 17."
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"Binding of LPS to TLR4 on KC, activating NF-kB, MAPK, ERK1, p38, JNK, and IRF3, induces the production of inflammatory cytokines and type I IFN, contributing to tissue damage, increase in leukocyte infiltration, and secretion of profibrogenic cytokines."
Lipopolysaccharide activates phosphorylated JNK. 1 / 1
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"Immunoblot analysis was performed with antibodies specific to phosphorylated JNK and p38 in PBMCs from HCs and AOSD patients treated with S100A9 or LPS for 4 h (XREF_FIG C)."
Lipopolysaccharide bound to CD14 receptor activates JNK. 1 / 1
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"LPS, the active component of endotoxins, interacts with LPS binding protein and the CD14 receptor, activating TLRs and, consequently, the inflammatory cascade that involves stress activated protein kinases, JNK, p38, interferon regulatory factor-3 (IRF-3) and NF-kappaB, pathways implicated in insulin resistance and triglycerides synthesis [XREF_BIBR, XREF_BIBR]."