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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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Lipopolysaccharide activates ERK. 10 / 982
| 2 957
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"Furthermore, avicularin significantly attenuated LPS induced activation of ERK signaling pathway."
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"LPS mediated MAPK activation and cytokine production were enhanced in LAB -/- DCs, suggesting that LAB has a negative role in LPS mediated responses."
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"We demonstrate that LPS stimulation may activate intracellular MAPK and JNK and NF-kappaB signaling pathways and thus induce cell apoptosis."
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"Meanwhile, LPS activated MAPK and PU.1 to induce L-PGDS expression, which contributes to the conversion of PGH 2 to PGD 2."
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"In addition, dioscoreanone in the range of 1.2-5microM significantly enhanced LPS induced ERK1/2 activation and dioscoreanone alone induced the activation of ERK1/2 proteins in a concentration- and time dependent response."
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"LPS induced activation of both p38 mitogen activated protein kinase (MAPK) and extracellular signal regulated kinase (ERK) in C6 cells."
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"Interestingly, other studies have shown that TGFbeta1 induced signaling inhibits LPS activation of MAPK and NFkappaB and the induction of pro inflammatory genes."
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"Our results suggest that the mechanism underlying the effects of MOA on inflammatory mediators involves the prevention of AP-1 nuclear translocation through the downregulation of ERK1/2 in the LPS activated MAPK pathway of RAW 264.7 cells."
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"Interestingly, confocal analysis clearly indicated that LPS treatment induced a condensed localization of ERK in the cytoplasm; under amentoflavone treatment, this pattern was only weakly visible (data not shown)."
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"LPS initiated the production of pro inflammatory cytokines by activating the MAPK and NF-kappaB cascades [XREF_BIBR]."
Lipopolysaccharide activates phosphorylated ERK. 9 / 31
| 29
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"LPS increased pERK, which was significantly different from all other groups (control, OUA and OUA+LPS) treated with the scrambled sequence."
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"Further, EtOH decreased p-ERK1/2 in BV2, whereas both LPS and Poly (I : C) increased p-ERK1/2, further distinguishing the signaling of ethanol from TLR3 and TLR4."
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"MKP-3 expression in primary astrocytes reduced LPS induced p-ERK and p-p38 by ~ 50%, and p-JNK by ~ 75%, and moderately reduced nitrite oxide (NO), while completely blocked Interleukin (IL) -6 and tumor necrosis factor alpha (TNFalpha)."
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"However, treatment for 48 h with 5 mug/ml LPS increased pERK 44 and 42 expression to 40.40 +/- 7.88 (p < 0.001, XREF_FIG) and 39.53 +/- 0.69 (p < 0.001, XREF_FIG) respectively."
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"LPS induced pERK, pRSK, p-p38, and NF-kB expression is reduced in macrophages co-cultured with MSCs."
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"After being pretreated with ketamine (100 and 250 muM) for 30 minutes, phosphorylated ERK1/2 stimulated by LPS (100 ng mL -1) was markedly inhibited by ketamine in a concentration dependent manner (XREF_FIG)."
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"After 30minutes, LPS caused an even more robust effect, by increasing p-ERK1/2 by 68% (+/-5.6%, p < 0.0001), p-p38 by 568% (+/-61%, p < 0.0001), and p-NFkappaB by 80% (+/-18%, p < 0.001) relative to controls."
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"The increase of phosphorylated ERK in the mice treated with LPS was accompanied by a significant increase in phospho-CREB-ir as a result of LPS treatment (F (3,19) = 9.64, p < 0.05)."
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"Another study showed that pretreatment with lycopene markedly inhibited the lipopolysaccharide (LPS)-induced up-regulation of p-ERK, p-p38, p-JNK, and NF-kappaB, suggesting an inhibitory effect by lycopene on MAPK and NF-kappaB signaling pathways."
Lipopolysaccharide activates ERK. 3 / 3
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"Figure 4A illustrates that CSE induces phosphorylation of both ERK and p38, although the magnitude of the early response was significantly less than that occurring with control DCs activated by Lps. We observed that LPS induces rapid phosphorylation of both ERK and p38 within 5-15 minutes of activation. CSE similarly induced phosphorylation of both ERK and p38 within 5-15 minutes of incubation (Figure 4A). "
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"Kinase activity was assessed in a kinetic study over 24 h, and actin was also immunoblotted as an internal loading control (Fig. 5A). Densitometry analysis was performed, and activities were presented as a fold increase above baseline (Fig. 5B). LPS rapidly induced activation of Akt and Erk1/2 within 15 min,"
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"2 hours after the LPS stimulation, the phosphorylation levels of ERK1/2, p38 MAPK and JNK all increased. "
Lipopolysaccharide bound to TLR4 activates ERK. 2 / 2
| 2
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"Binding of LPS to TLR4 on KC, activating NF-kB, MAPK, ERK1, p38, JNK, and IRF3, induces the production of inflammatory cytokines and type I IFN, contributing to tissue damage, increase in leukocyte infiltration, and secretion of profibrogenic cytokines."
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"For example, LPS binds to TLR-4 and activates the MAPK pathway, which activates NF-kappaB."
Lipopolysaccharide bound to EPHX2 activates ERK. 1 / 1
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"Herein, we demonstrate that podocyte specific sEH genetic disruption in vivo and pharmacological inhibition in podocytes were associated with decreased LPS induced inflammation, MAPK activation, and ER stress."
Lipopolysaccharide bound to Toll-like receptors activates ERK. 1 / 1
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"The binding of lipopolysaccharide to Toll like receptors causes phosphorylation of Cot and Tp12 to activate the MAPK cascade."