IndraLab

Statements

Erlotinib leads to the phosphorylation of AKT. 10 / 19
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"By contrast, phosphorylation of Akt was partially suppressed by erlotinib in EGFR knockdowned PC9 and ER1cells (XREF_FIG)."
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"Erlotinib led to the dephosphorylation of EGFR in H1650 and HCC827 but not in H1975 cells (Fig. 1C). However, although the dephosphorylation of EGFR was accompanied by a reduction in p-Akt levels in erlotinib-sensitive HCC827 cells, H1650 cells retained high levels of p-Akt despite inhibition of EGFR (Fig. 1C)."
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"In NSTS-47 cells, sunitinib and erlotinib decreased the phosphorylation of PDGFR-beta, EGFR and Akt, but for yet unknown reasons, MEK1/2 and ERK1/2 kinases remained phosphorylated at levels that were comparable with those detected in untreated cells.Interestingly, incomplete penetrance of the c.1681C>T (p.R561C) mutation was found in a family with two children suffering from IM [19]."
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"On the contrary, erlotinib stimulated Akt phosphorylation in both cell lines and in HCT116 cells Erk was activated."
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"Although the combined regimen of sertraline and erlotinib significantly suppressed the phosphorylation of AKT and ERK, these effects were largely due to potent inhibition of these signaling molecules by erlotinib alone."
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"Erlotinib was proposed to down-regulate activated phosphorylation of Akt induced by the mTOR inhibitor rapamycin, and thus produce a synergistic anti-tumor effect."
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"We found that erlotinib inhibits the phosphorylation of EGFR and ErbB3 in PC-9 and Vec cells, thereby inhibiting the phosphorylation of Akt and extracellular signal regulated kinase 1/2 (ERK1/2)."
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"In cell lines with aberrant NRG1-expression, exposure to GSK2849330, afatinib, erlotinib, and neratinib significantly inhibited growth and suppressed ErbB2, ErbB3, and AKT phosphorylation."
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"Erlotinib and osimertinib similarly inhibited the phosphorylation of EGFR, AKT, and ERK."
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"The EGFR inhibitor erlotinib, used as a positive control, inhibited the phosphorylation of EGFR, ERK1/2, and AKT (XREF_FIG)."
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Erlotinib leads to the phosphorylation of AKT on H3255. 1 / 1
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"Although less potent than afatinib, erlotinib and osimertinib effectively inhibited the phosphorylation of EGFR, AKT, and ERK in PC-9 and H3255."
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