IndraLab

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CDK4 phosphorylates RB1. 10 / 750
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"The first one refers to the extent to which Cdk4 contributes to the pseudo-hyper-phosphorylation of pRb, whereas the second one refers to the metabolic rate of the cell."
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"Many studies have shown that the cyclin D1 and CDK4 complex enters the nucleus and phosphorylates RB family proteins during the cell cycle control of proliferating cells."
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"For this purpose, cyclinD1 and Cdk4 phosphorylates only RB, but not FOXM1c, so that cyclinD1 and Cdk4 increases the transcriptional activity of FOXM1c without phosphorylating FOXM1c and activates FOXM1c independently of cyclin and Cdk phosphorylation sites in FOXM1c."
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"Finally, CDK4 and CDK6 may have different preferences for phosphorylation of specific sites in pRb protein [ xref ], and we have recently found distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3 [ xref ]."
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"The CDK4 (or CDK6) catalytic complex acts early in G1 to phosphorylate Rb [XREF_BIBR - XREF_BIBR]."
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"XREF_BIBR In late G 1, a significant hyperphosphorylation of the pRB by CDK4 and CDK6 in complex with D cyclins (D1, D2, D3) occurs."
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"Furthermore, we identified their expression levels of CDK4 and phosphorylated RB1 were reduced in response to miR p-27-5p over-expression."
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"Cyclin D1 can bind to and activate CDK4 and CDK6, which phosphorylates RB protein and promotes the release of E2F and cell cycle progression."
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"For example, gankyrin competes with p16 for binding to CDK4, thus blocking the CDK4-inhibitory activity of p16; p34 SEI1 (SERTAD1) is able to bind to the CDK4-cyclin D1 complex and enhance the latter 's kinase activity; BMI1 (B lymphoma Mo-MLV insertion region 1 homolog, a polycomb ring finger protein) down-regulates the expression of p16 (CDKN2A) and p15 (CDKN2B) genes, which consequently promotes CDK4 mediated phosphorylation of pRb."
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"Cyclin D1 and the CDK4 complex phosphorylate pRB, allowing entry into the cell cycle [27,28,29] ."
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