IndraLab

Statements

BRAF phosphorylates MAP2K1. 10 / 58
1 | 1 16 32 6
reach
"We observed that 65% of anti-BRAF autoantibodies activate phosphorylation of MEK1 by BRAF in vitro."
20955560
reach
"BRAF proteins, Ras regulated kinase, phosphorylate MEK1 and MEK2, which in turn phosphorylate MAPK-ERK 1/2."
16404419
rlimsp
"Phosphorylation of MEK1 by BRAF was detected by Western blotting and quantified."
20955560
sparser
"We found that not BRAF WT but BRAF V600E-dependent phosphorylation of MEK1 was increased in the presence of AA ( Figure S5 D)."
26145173
reach
"BRAF, also known as serine/threonine protein kinase B-Raf, can phosphorylate MAP2K1 and thereby activates the MAP kinase signal transduction pathway in living cells."
33240890
sparser
"Activated BRAF proteins phosphorylates and activates MEK1 and 2 (MAPKKs), which in turn phosphorylate and activate ERK1 and 2 (MAPKs)."
19383316
sparser
"We confirmed that B-Raf activated by cAMP phosphorylates the sites in MEK-1 (serines 218 and 222) that have previously been shown to be required for MEK activation by Raf-1 ( Alessi et al. 1994 )."
9094716
reach
"When BRAF is inhibited, ERK can still be activated through CRAF, and BRAF binds to and phosphorylates MEK1 and MEK2 more efficiently than CRAF [XREF_BIBR], especially in his V600E/K mutated form."
33507915
sparser
"In the context of melanoma, oncogenic BRAF V600E constitutively phosphorylates and activates the MEK1 and MEK2 kinases, which in turn phosphorylate and activate the ERK1 and ERK2 kinases, hyperactivating the canonical Mitogen Activated Protein Kinase Pathway (MAPK) to promote uncontrolled melanocytes growth and caner initiation and progression xref ."
31317143
rlimsp
"Autoantibodies to BRAF activate the phosphorylation of MEK1 by BRAF."
20955560
BRAF phosphorylates MAP2K1 on S218. 10 / 16
6 1 1 4 | 1 1 2
biopax:pid
No evidence text available
7731720
sparser
"B-Raf phosphorylates MEK1 and MEK2 on Ser217 and Ser221, which activates it to dual phosphorylate ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2 [ xref , xref ]."
16255777
rlimsp
"B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222."
7731720
reach
"B-Raf phosphorylates MEK1 and MEK2 on Ser217 and Ser221, which activates it to dual phosphorylate ERKs, at Thr202 and Tyr204 for human ERK1 and Thr185 and Tyr187 for human ERK2 [XREF_BIBR, XREF_BIBR]."
16255777
biopax:phosphositeplus
No evidence text available
hprd
No evidence text available
8394352
biopax:pid
No evidence text available
15342917
biopax:pid
No evidence text available
17563371
hprd
No evidence text available
8621729
hprd
No evidence text available
7731720
BRAF phosphorylates MAP2K1 on S222. 10 / 14
6 1 1 4 | 1 1
sparser
"B-Raf phosphorylates MEK1 and MEK2 on Ser217 and Ser221, which activates it to dual phosphorylate ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2 [ xref , xref ]."
16255777
hprd
No evidence text available
8157000
biopax:pid
No evidence text available
16135787
biopax:phosphositeplus
No evidence text available
reach
"B-Raf phosphorylates MEK1 and MEK2 on Ser217 and Ser221, which activates it to dual phosphorylate ERKs, at Thr202 and Tyr204 for human ERK1 and Thr185 and Tyr187 for human ERK2 [XREF_BIBR, XREF_BIBR]."
16255777
biopax:pid
No evidence text available
7731720
biopax:pid
No evidence text available
15342917
signor
"Raf-1 phosphorylation of MEK activated it, as judged by its ability to stimulate the phosphorylation of myelin basic protein by glutathione S-transferase-ERK1."
8413257
hprd
No evidence text available
7731720
biopax:pid
No evidence text available
7706312
BRAF-V600E phosphorylates MAP2K1. 4 / 5
| 4
reach
"In the RAF-MEK-ERK pathway, BRAF V600E results in constitutive phosphorylation of MEK1 (encoded by MAP2K1), which then activates ERK by phosphorylation, leading to malignant proliferation [4,6,98]."
| PMC
reach
"Immunoprecipitated BRAF (V600E) phosphorylated MEK1 protein in vitro (XREF_FIG, lane 5), however, treatment with 17-DMAG clearly inactivated the kinase activity of BRAF (V600E) (XREF_FIG, lane 6), even though equivalent levels of BRAF (V600E) protein were utilized from treated and non treated cell lysates (XREF_FIG, lanes 3 and 4)."
18676857
reach
"BRAF V600E increases 3-hydroxy-3-methylglutaryl-CoA lyase, intracellular levels of acetoacetate, and MEK1 phosphorylation, suggesting that there is crosstalk between metabolic pathways and cell signaling networks."
28828350
reach
"Although both BRAF V600E or BRAF WT phosphorylates MBP but such phosphorylation was not affected in the presence of increasing concentrations of acetoacetate or 3-HB (XREF_FIG and XREF_SUPPLEMENTARY), suggesting that acetoacetate may specifically affect BRAF V600E dependent phosphorylation of MEK1."
26145173
BRAF phosphorylates MAP2K1 on serine. 2 / 2
| 1 1
reach
"BRAF phosphorylates regulatory serine residues on MEK1 and MEK2 and mutation of BRAF results in activation of the RAS/RAF/MEK/ERK pathway, leading to cellular proliferation and a series of anti-apoptotic and potentially immunoregulatory events that culminate in the progression of this tumor."
22876817
sparser
"BRAF phosphorylates regulatory serine residues on MEK1 and MEK2 and mutation of BRAF results in activation of the RAS/RAF/MEK/ERK pathway, leading to cellular proliferation and a series of anti-apoptotic and potentially immunoregulatory events that culminate in the progression of this tumor."
22876817
BRAF phosphorylated on T373 phosphorylates MAP2K1 on S222. 2 / 2
2 |
biopax:pid
No evidence text available
7935374
biopax:pid
No evidence text available
9560161
BRAF phosphorylated on T373 phosphorylates MAP2K1 on S218. 2 / 2
2 |
biopax:pid
No evidence text available
9560161
biopax:pid
No evidence text available
7935374
BRAF phosphorylates MAP2K1 on S248. 1 / 1
1 |
signor
"Raf-1 phosphorylation of MEK activated it, as judged by its ability to stimulate the phosphorylation of myelin basic protein by glutathione S-transferase-ERK1."
8413257
BRAF phosphorylates MAP2K1 on S252. 1 / 1
1 |
signor
"Raf-1 phosphorylation of MEK activated it, as judged by its ability to stimulate the phosphorylation of myelin basic protein by glutathione S-transferase-ERK1."
8413257