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Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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BDNF activates PLCG1. 7 / 11
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"BDNF triggers TrkB and PLCgamma1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis."
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"Brain derived neurotrophic factor and TrkB can facilitate the dimerization and phosphorylation of TrkB and can thereby activate MAPK, PIK3 and phospholipase C-gamma1 signalling pathways to protect hippocampal neurons from damage induced by glutamate 70 and ischaemia 71."
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"We propose a model whereby release of BDNF from mossy fiber filopodia activates TrkB and PLCg1 signaling postsynaptically within SLINs, triggering synthesis and release of an endocannabinoid that serves as retrograde signal, culminating in reduced glutamate release."
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"Overall, these results show that PSD-95 plays a key role in BDNF induced PLCgamma1 and PI3K signaling, and suggest that in Ube3A deficient neurons the association of PSD-95 with TrkB is decreased, resulting in defective signaling."
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"pY816 peptide inhibits BDNF mediated activation of PLCgamma1."
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"In stable cell lines over-expressing dog TrkB, we observed that both BDNF and TAM-163 increased pTrkB, pPLCgamma1 and pERK1/2 in a dose dependent manner (XREF_SUPPLEMENTARY), confirming the cross-reactivity of TAM-163 with this species."
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"We next tested whether the presence of PSD-95 is required for BDNF induced PLCgamma1 and PI3K signaling."