"Inhibition of AKT activity restricts myeloid and erythroid differentiation of human HSPCs."
"Many signalings were coupled to CD40; for example, P38 MAPK and TNFalpha and PI3K and Akt / NF-kappab have been shown to enlarge systemic inflammation and promote differentiation of Th1 and Th17."
"The PI3K and AKT pathway is also known to induce osteoblast differentiation under stimulation by BMP-2 15."
"Our results show that IGFBP2 overexpression activates phosphorylation of JNK and Akt signaling, and activated JNK or Akt signaling enhances adipogenic differentiation of MSCs."
"We further studied the effects of reduced cytokine dependent Akt activation in erythroid differentiation."
"Upstream activation of PI3K and AKT signaling and downstream events, including FOSL1 partners and specific transcriptional targets, mediating invasive trophoblast differentiation remain to be elucidated."
"Moreover, the Akt signaling pathway is important in transducing the proadipogenic effects of insulin [XREF_BIBR] and promotes adipocyte differentiation through increase of PPAR-gamma expression."
"The stimulation of NGF activates the PI3K and Akt pathway promotes cellular proliferation, differentiation, and survival."
"Together, increased Epo, Akt signaling, Gata1 activity, and iron accumulation support increased erythroid differentiation and proliferation in the BM (XREF_FIG), an expected response to 2-BE treatment due to its hemolytic effects."
"Expression of active Akt in keratinocytes promotes growth arrest and differentiation, whereas pharmacological blockade of PI3K inhibits the expression of " late " differentiation markers and leads to death of cells that would otherwise differentiate."