A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

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"Inhibition of AKT activity restricts myeloid and erythroid differentiation of human HSPCs."
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"Many signalings were coupled to CD40; for example, P38 MAPK and TNFalpha and PI3K and Akt / NF-kappab have been shown to enlarge systemic inflammation and promote differentiation of Th1 and Th17."
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"The PI3K and AKT pathway is also known to induce osteoblast differentiation under stimulation by BMP-2 15."
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"Our results show that IGFBP2 overexpression activates phosphorylation of JNK and Akt signaling, and activated JNK or Akt signaling enhances adipogenic differentiation of MSCs."
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"We further studied the effects of reduced cytokine dependent Akt activation in erythroid differentiation."
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"Upstream activation of PI3K and AKT signaling and downstream events, including FOSL1 partners and specific transcriptional targets, mediating invasive trophoblast differentiation remain to be elucidated."
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"Moreover, the Akt signaling pathway is important in transducing the proadipogenic effects of insulin [XREF_BIBR] and promotes adipocyte differentiation through increase of PPAR-gamma expression."
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"The stimulation of NGF activates the PI3K and Akt pathway promotes cellular proliferation, differentiation, and survival."
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"Together, increased Epo, Akt signaling, Gata1 activity, and iron accumulation support increased erythroid differentiation and proliferation in the BM (XREF_FIG), an expected response to 2-BE treatment due to its hemolytic effects."
Phosphorylated AKT activates cell differentiation. 5 / 5
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"Taken together, our results demonstrate that over-expression of CHL1 inhibits the activation of Rho GTPases, of related p38 and JNK MAPK pathways, and of p-Akt inducing cell apoptosis and differentiation."
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"Moreover, loss of METTL3 leads to increased levels of phosphorylated AKT, which contributes to the differentiation promoting effects of METTL3 depletion."
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"Upregulating p-AKT could increase the neuronal differentiation from mouse cochlear neural stem cells."
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"Previous reports are consistent with our results showing increased p-Akt expression during matrix induced osteogenic differentiation."
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"Moreover, IGFBP2 increased phosphorylation of c-Jun N-terminal kinase (p-JNK) and p-Akt, and activated JNK or Akt signaling significantly promoted adipogenic differentiation of MSCs."
Modified AKT activates cell differentiation. 1 / 1
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"Xu et al. showed that the expression of Akt induces an important association between the PI3-kinase-PKB and Akt signal cascade and the transcription factors PPARgamma and C/EBPalpha in the induction of 3T3-L1 adipocyte differentiation [XREF_BIBR]."
Kinase-active AKT activates cell differentiation. 1 / 1
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bel
"In keratinocytes, exogenous expression of membrane tethered, constitutively active Akt was found to be sufficient in driving cell-cycle exit and onset of terminal differentiation, underscoring the importance of Akt in this process (Calautti et al., 2005)."
AKT bound to PHB2 activates cell differentiation. 1 / 1
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"Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation."