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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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AKT increases the amount of BCL2. 10 / 97
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"Akt also has been reported to stimulate the expression of anti-apoptotic Bcl-2 proteins, such as Bcl-xL through the activation of NF-kappaB [XREF_BIBR, XREF_BIBR]."
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"It has been reported that Akt upregulates Bcl-2 expression whose promoter region contains a cAMP response element (CRE) site [XREF_BIBR - XREF_BIBR]."
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"To examine whether PI3K and Akt signaling contributes to the expression of Bcl2 in H/R injury, we measured the mRNA level of Bcl2 by RT-PCR (XREF_FIG), as Bcl2 correlates with activation of cell survival signaling."
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"Additionally, we demonstrated that blockade of PI3K and AKT signaling pathway by wortmannin (WM) impaired the expression of Bcl-2 and Bcl XL in the primary AML cells, suggesting an essential cross-talk between PI3K and Bcl-2 that maintains the survival of AML cells."
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"Meanwhile, Bcl-2 has strong antioxidant activity, and PI3K and AKT and ERK can up-regulate the expression level of Bcl-2 to inhibit ROS generation in ischaemic damage XREF_BIBR XREF_BIBR XREF_BIBR."
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"Akt regulation of ERalpha on a post-translational level, may lead to increased Bcl-2 expression."
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"Meanwhile, Bcl-2 has strong antioxidant activity, and PI3K and AKT and ERK can up-regulate the expression level of Bcl-2 to inhibit ROS generation in ischemic damage [XREF_BIBR, XREF_BIBR]."
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"Activation of Akt stimulates expression of Bcl-2 and inhibits the expression of Bad, thus inhibiting the execution of apoptosis."
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"MIF [XREF_BIBR], an ERK activator inducing Bcl-2 expression, and AKT, or PKCepsilon [XREF_BIBR], responsible for MAPK activation, are both reported to be involved in the modulation of apoptosis in SSc fibroblasts."
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"TxA2 activates the transcriptional factor CREB through both ERK and PI3K and AKT pathways, which may also lead to PCNA and Bcl-2 overexpressions and cell proliferation [XREF_BIBR]."
Phosphorylated AKT increases the amount of BCL2. 10 / 10
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"The data obtained in the MSC-ERBB4 suggested that the NRG1-ERBB4 pathway functioned through phosphorylated activation of Akt that further upregulated Bcl-2 expression and thereby protected cells from apoptosis."
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"Our results demonstrated that EGCG suppressed neuronal apoptosis, increased Bcl-2 expression, decreased Caspase-3 and Bax expression, and upregulated eNOS, PI3K, and p-AKT expression."
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"In addition to Brn3b mediated elevation in Bcl-2 expression, it is possible that a transient elevation in p-AKT could promote increased Bcl-2 expression, contributing to increased RGC survival."
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"The inhibition of AKT phosphorylation could downregulate the expression of Bcl-2 and the ratio of Bcl-2 and Bax, and upregulate the level of hepatocyte apoptosis."
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"Blockade of Akt phosphorylation abrogated VEGF-C-induced Bcl-2 expression in lymphatic endothelial cells, demonstrating the requirement of Akt signaling in this process (XREF_FIG)."
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"In addition, p-Akt and p-GSK3beta have been reported to upregulate the expression of Bcl-2 and Bcl-xL, and increase the Bcl-2 and Bax ratio."
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"Phosphorylation of Akt was able to significantly up-regulate the expression of Bcl-2, and down-regulate the expression of Bax in gastric cancer."
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"Pretreatment with luteolin can also upregulate the expression of phosphorylated Akt, which further promotes the expression of Bcl-2 and Bad while downregulating the expression of Bax thereby decreasing apoptosis."
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"We found that in spinal cord neurons, phosphorylation of AKT by activation of the IL-10 receptor resulted in activation of the canonical NF-kappaB pathway, increased nuclear p50 and p65 and enhanced Bcl-2 and Bcl-x L transcription."
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"In gastric cancer cells phosphorylation of Akt mainly upregulates the expression of Bcl-2 and downregulates the expression of Bax [XREF_BIBR]."
Modified mutated AKT increases the amount of BCL2. 2 / 2
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"In retrovirally infected mouse marrow cells, the BCR and ABL mutant lacking the SH2 domain was unable to upregulate the expression of c-Myc and Bcl-2; in contrast, expression of a constitutively active Akt mutant induced Bcl-2 and c-Myc expression, and stimulated the transcription activation function of c-Myc."
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"Expression of catalytically active Akt mutants in BAF/3 cells expressing IL-2R beta [A0] delta S promotes the expression of Bcl-2 and c-myc, inhibits apoptosis induced by IL-3 deprivation or staurosporine, and stimulates cell cycle progression."
Modified AKT increases the amount of BCL2. 1 / 1
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"The increased protein Akt phosphorylation expression levels resulted in consequent reduced downstream caspase-3 expression and enhanced Bcl-2 expression."
Kinase-active AKT increases the amount of BCL2. 1 / 1
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"Overexpression of DN Akt blocked or reduced HGF-induced increase in Bcl-2, Egr-1, c-fos, ornithine decarboxylase, and COX-2 expression detected by the microarray (data not shown)."