"Akt also has been reported to stimulate the expression of anti-apoptotic Bcl-2 proteins, such as Bcl-xL through the activation of NF-kappaB [XREF_BIBR, XREF_BIBR]."
"It has been reported that Akt upregulates Bcl-2 expression whose promoter region contains a cAMP response element (CRE) site [XREF_BIBR - XREF_BIBR]."
"To examine whether PI3K and Akt signaling contributes to the expression of Bcl2 in H/R injury, we measured the mRNA level of Bcl2 by RT-PCR (XREF_FIG), as Bcl2 correlates with activation of cell survival signaling."
"Additionally, we demonstrated that blockade of PI3K and AKT signaling pathway by wortmannin (WM) impaired the expression of Bcl-2 and Bcl XL in the primary AML cells, suggesting an essential cross-talk between PI3K and Bcl-2 that maintains the survival of AML cells."
"Meanwhile, Bcl-2 has strong antioxidant activity, and PI3K and AKT and ERK can up-regulate the expression level of Bcl-2 to inhibit ROS generation in ischaemic damage XREF_BIBR XREF_BIBR XREF_BIBR."
"Akt regulation of ERalpha on a post-translational level, may lead to increased Bcl-2 expression."
"Meanwhile, Bcl-2 has strong antioxidant activity, and PI3K and AKT and ERK can up-regulate the expression level of Bcl-2 to inhibit ROS generation in ischemic damage [XREF_BIBR, XREF_BIBR]."
"Activation of Akt stimulates expression of Bcl-2 and inhibits the expression of Bad, thus inhibiting the execution of apoptosis."
"MIF [XREF_BIBR], an ERK activator inducing Bcl-2 expression, and AKT, or PKCepsilon [XREF_BIBR], responsible for MAPK activation, are both reported to be involved in the modulation of apoptosis in SSc fibroblasts."
"TxA2 activates the transcriptional factor CREB through both ERK and PI3K and AKT pathways, which may also lead to PCNA and Bcl-2 overexpressions and cell proliferation [XREF_BIBR]."