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"Finally, previous work by our group and others provided evidence that Akt can phosphorylate Rac1 at Ser 71 and that this effect is correlated with reduced Rac1 activation ( xref ; xref )."

"For example, AKT phosphorylation of serine71 on Rac1 enhances guanine diphosphate binding [ xref ]."

"Rac1 is phosphorylated on S71 by Akt, leading to inhibition of GTP binding, but not Rac1 GTPase activity [ xref ]."

"Finally, previous work by our group and others provided evidence that Akt can phosphorylate Rac1 at Ser 71 and that this effect is correlated with reduced Rac1 activation."

"Ser‐71 phosphorylated Rac1/Cdc42 appear to be in their active conformation according to pull‐down assay with PAK CRIB‐domain and Rho‐GDI. xref Both Rac1 and Cdc42 belong to GTPases of the Rho subfamily that exert on the actin cytoskeleton as well as differentiation and function of osteoclast. xref , xref However, evidence showed that the phosphorylation of Rac1 at Ser‐71 by Akt may inhibit GTP binding of Rac1, attenuating the signal transduction pathway downstream of Rac1. xref , xref , xref It is quite possible that the enhanced phosphorylation of Cdc42 can be associated with the augmented osteoclast differentiation in the ADOII patient."

"It is not clear whether Rac1 is a phosphorylation target for PKA, but Kwon et al. demonstrated phosphorylation of Rac1 on Ser-71 by Akt in human melanoma cells xref ."

"Rac1 can also be phosphorylated by the Akt kinase at Ser 71, which is embedded in the consensus sequence 64 ydRIRplSYp 73."

"Rac1 enhances tissue invasion of prostate cancer cells by activating Rho GTPases and promoting activation of MMPs [ xref , xref ], and Akt phosphorylates Rac1 at Ser71 to inhibit its GTPase activity [ xref , xref ]."

"Rac1 is phosphorylated on S71 by Akt, leading to inhibition of GTP binding, but not Rac1 GTPase activity [XREF_BIBR]."

No evidence text available

"For instance, our studies showed that extranuclear signaling by E2 can activate the pro survival kinase, Akt which phosphorylates Rac1 and inhibits its activation."

"Unlike its regulation of RhoA, the ubiquitination of Rac1 by SCF FBXL19 is accompanied by the phosphorylation of Rac1 by AKT."

"Furthermore, we recently demonstrated that enhanced Akt activation leads to phosphorylation of Rac1 and deactivation of MLK3 in hippocampus CA1 following tyrosine phosphatase inhibition in animals that had undergone global cerebral ischemia."

"Phosphorylation of Rac1 by Akt kinase was assayed with recombinant Rac1 protein and the fluorescein-labeled Rac1 peptide."

"Phosphorylation of Rac1 by Akt kinase was assayed with recombinant Rac1 protein and the fluorescein labeled Rac1 peptide."

"Akt can phosphorylate in vitro the Rho GTPase Rac1, inhibiting its GTP binding activity 41; the relevance of this observation to cell motility is not yet established."

"Rac1 is phosphorylated on 71 S by Akt, which does not change Rac1 GTPase activity of Rac1, but inhibits its binding to GTP [ xref ]."

"We confirmed that inhibition of PI3K and Akt significantly decreased Rac1 phosphorylation in cultured human keratinocytes (XREF_FIG)."

"Ser71 (64yrplsyp73) is a conserved Akt site on RAC1 that can be phosphorylated by Akt."

"For instance, our studies showed that extranuclear signaling by E2 can activate the pro-survival kinase, Akt which phosphorylates Rac1 and inhibits its activation."

"Fourth, Akt phosphorylates serine 71 of Rac1 thereby modulating the Rac1 signal transduction pathway in SK-MEL-28 melanoma cells."

"Thus, the results suggest that Akt kinase of the phosphoinositide 3-kinase signal transduction pathway phosphorylates serine 71 of Rac1 as one of its authentic substrates and modulates the Rac1 signal transduction pathway through phosphorylation."

"On the other hand, phosphorylation of serine 71 on Rac1 by serine/threonine kinase Akt seems to have different effects - inhibiting the GTP binding activity of Rac1 with no significant change in GTPase activity [XREF_BIBR]."

"On the other hand, phosphorylation of serine 71 on Rac1 by serine/threonine kinase Akt seems to have different effects - inhibiting the GTP binding activity of Rac1 with no significant change in GTPase activity [XREF_BIBR]."

"Fourth, Akt phosphorylates serine 71 of Rac1 thereby modulating the Rac1 signal transduction pathway in SK-MEL-28 melanoma cells."

"Thus, the results suggest that Akt kinase of the phosphoinositide 3-kinase signal transduction pathway phosphorylates serine 71 of Rac1 as one of its authentic substrates and modulates the Rac1 signal transduction pathway through phosphorylation."

"PhosphoElm data from PMID 15212693"

"Phosphorylation of Rac1 by Akt kinase was assayed with recombinant Rac1 protein and the fluorescein-labeled Rac1 peptide. It was shown that the Rac1 peptide and the recombinant protein were phosphorylated by the activated recombinant Akt kinase and the lysate of SK-MEL28 cells, a human melanoma cell line."