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IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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AKT increases the amount of SERPINE1. 7 / 8
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"As shown in XREF_SUPPLEMENTARY, activation of Akt by expressing a constitutively active C/A-Akt indeed induced expression of PAI-1 and CTGF in Smad3 +/+ cells, but not in Smad3 -/- cells."
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"Inhibition of the PI3K and Akt pathway abrogates TGF-beta-induced PAI-1 expression by disrupting the TGF-beta-induced interaction of transcriptional coactivator and acetyltransferase CBP with activated Smad3."
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"In contrast, constitutively active PI 3 kinase and Akt kinase increased PAI-1 expression, similar to TGFbeta."
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"An expanded analysis of the murine fibrosarcoma cells discussed above revealed that PAI-1 deficient fibrosarcomas have reduced Akt signaling and reintroduction of PAI-1 expression in deficient cells results in an increase in Akt signaling [XREF_BIBR]."
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"These findings indicate that p38- and PKB dependent signalling pathways contribute to enhanced PAI-1 levels in the hypoxic response."
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"Indeed, direct activation of Akt by expressing a constitutively active form of C/A-Akt induces expression of fibrotic response gene PAI-1 and CTGF in Smad3 +/+ cells, but not in Smad3 -/- cells (XREF_SUPPLEMENTARY)."
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"Furthermore, the administration of Akt activity inhibitors greatly diminished the expression of NF-kappaB and PAI-1."
Kinase-active AKT increases the amount of SERPINE1. 1 / 1
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"Hence, we conclude that the induction of PAI-1 gene expression is cell adhesion dependent and is through PI-3 kinase and Akt activation."
Modified AKT increases the amount of SERPINE1. 1 / 1
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"Consistently, overexpression of PKB or of the p38 upstream kinases MKK6 and MKK3 and of JNK, but not of ERK, enhanced PAI-1 mRNA levels."