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IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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AKT increases the amount of MDM2. 8 / 14
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"The use of DN-Akt and CA-Akt confirmed that Akt modulates the levels of MDM-2, p53, and p63 in RCC cells (XREF_FIG)."
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"(2) Inhibition of AKT decreased the phosphorylation level of MDM2, and then increased the protein level of P53 which would accelerate death proceeding of tumor cells."
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"As shown on XREF_FIG, activation of AKT signaling by HRG effectively induced MDM2 protein expression, which was completely blocked by rapamycin in both MCF-7 and H1299 cells (XREF_FIG)."
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"Interestingly, romidepsin induced p21 involves Akt induced Mdm2 in a p53 independent manner by downregulating Akt and Mdm2 protein levels."
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"Interestingly, the protein levels of HDM2 are not increased following H. pylori infection, but rather the levels of its phosphorylation by AKT kinase."
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"Inhibition of AKT pathway reduces the cellular levels of p21 and MDM2, which in turns increases the expression of p53, resulting in cell death and cell cycle arrest [XREF_BIBR, XREF_BIBR]."
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"Our data suggest that stabilization of MDMX by Akt may be an alternative mechanism by which Akt up-regulates MDM2 protein levels and exerts its oncogenic effects on p53 in tumor cells."
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"Blockage of PI3K and Akt downregulated the expression of p-Mdm2 and total Mdm2."
Phosphorylated AKT increases the amount of MDM2. 1 / 1
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"Inhibition of AKT phosphorylation with phosphatidylinositol-3-kinase (LY294002) decreased MDM2 levels concomitantly with upregulation of p53, providing evidence that H. pylori inhibits p53 through the AKT-MDM2 signaling."
Kinase-active AKT increases the amount of MDM2. 1 / 1
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"AKT promotes the nuclear translocation of MDM2, thereby negatively regulating p53-mediated apoptosis"