IndraLab

Statements

AKT decreases the amount of SMAD3. 2 / 2
| 2
reach
"Therefore, Akt activation downregulates SMAD3 gene expression in ECs."
23963623
reach
"As shown in XREF_SUPPLEMENTARY, active Akt reduced the levels of SMAD3 in HUVECs, but the SMAD3 of the bone marrow stromal cells remained unperturbed."
23963623
AKT bound to SMAD3 decreases the amount of SMAD3. 1 / 1
| 1
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"The interaction between AKT and SMAD3 prevents ALK5 mediated phosphorylation and the nuclear localization of SMAD3, which leads to the inhibition of SMAD3 mediated transcription."
29113242
Kinase-active AKT decreases the amount of SMAD3. 1 / 1
1 |
bel
"Recent studies have identified a direct interaction of Akt with Smad3 that prevents Smad3 phosphorylation and Smad3 nuclear translocation, and inhibits both Smad3- mediated transcriptional events and apoptosis."
15774796