A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

AKT increases the amount of HIF1A. 7 / 71
| 62
reach
"Under hypoxia, the AKT pathway significantly increases the expression of hypoxia inducible factor-1alpha (HIF-1alpha), which further affects the phosphorylation of AKT."
reach
"XREF_BIBR HIF signalling has been linked to the regulation of myeloid cell survival, XREF_BIBR and HIF-1alpha expression is increased by activation of the PI3K and Akt pathway, XREF_BIBR a signaling cascade known to be dysregulated in AML."
reach
"Studies have shown that Akt can augment HIF-1alpha expression by increasing its translation under both normoxic and hypoxic conditions [XREF_BIBR - XREF_BIBR]."
reach
"Inhibition of the PI3K and Akt pathway by treatment with LY294002 (PI3K inhibitor) decreased the expression of HIF-1alpha and VEGF-A (XREF_SUPPLEMENTARY)."
reach
"For example, forced PTEN overexpression reduces HIF1alpha expression, whereas activated PI3K and AKT signaling upregulates HIF1alpha expression [XREF_BIBR, XREF_BIBR]."
reach
"On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K and Akt signaling."
reach
"Akt and mTORC1 increase HIF1alpha protein levels and knockdown of cavin-3 progressively increased both HIF1alpha levels and the use of fermentative glycolysis (XREF_FIG)."
Modified AKT increases the amount of HIF1A. 3 / 3
| 3
reach
"We found that over-expression of AKT by infecting ovarian cancer cells using adenovirus carrying AKT did restore HIF-1alpha expression inhibited by acacetin (XREF_FIG)."
reach
"Western blot analysis and reverse transcription-polymerase chain reaction in cell experiments revealed that the over-expression of constitutively active AKT (CA-AKT) promotes the expressions of HIF-1alpha protein and VEGF messenger ribonucleic acid in Seoul national university (SNU) -216 and SNU-668 gastric cancer cells under normoxic conditions, whereas kinase dead mutant of AKT down-regulated these expressions under the same conditions."
reach
"Similarly, expression of AKT dominant negative mutant also inhibited angiogenesis and tumor growth, and decreased the expression of HIF-1alpha and VEGF in the tumor xenographs."
Phosphorylated AKT increases the amount of HIF1A. 3 / 3
| 3
reach
"The expression of HIF-1alpha might be activated by AKT phosphorylation, as we previously reported XREF_BIBR, whereas the over-expression of CypA might stimulate the proliferation of human pancreatic cancer cells by activating the ERK1/2 and p38 pathways XREF_BIBR - XREF_BIBR."
reach
"Significantly, ruscogenin decreased the levels of MMP-2, MMP-9, uPA, VEGF and HIF-1alpha, down-regulated the phosphorylation of Akt, mTOR."
reach
"The hypoxic culture stimulated the phosphorylation of ERK1/2 and Akt induced HIF-1alpha expression."
Kinase-active AKT increases the amount of HIF1A. 1 / 1
1 |
bel
"In pVHL-deficient renal cell carcinoma cells, PI3K inhibition by LY294002 and wortmannin or transfection of either a dominant negative PI3K or a kinase-dead Akt mutant substantially lowered constitutively expressed HIF-1alpha without altering HIF-1alpha mRNA."