"Under hypoxia, the AKT pathway significantly increases the expression of hypoxia inducible factor-1alpha (HIF-1alpha), which further affects the phosphorylation of AKT."
"XREF_BIBR HIF signalling has been linked to the regulation of myeloid cell survival, XREF_BIBR and HIF-1alpha expression is increased by activation of the PI3K and Akt pathway, XREF_BIBR a signaling cascade known to be dysregulated in AML."
"Studies have shown that Akt can augment HIF-1alpha expression by increasing its translation under both normoxic and hypoxic conditions [XREF_BIBR - XREF_BIBR]."
"Inhibition of the PI3K and Akt pathway by treatment with LY294002 (PI3K inhibitor) decreased the expression of HIF-1alpha and VEGF-A (XREF_SUPPLEMENTARY)."
"For example, forced PTEN overexpression reduces HIF1alpha expression, whereas activated PI3K and AKT signaling upregulates HIF1alpha expression [XREF_BIBR, XREF_BIBR]."
"On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K and Akt signaling."
"Akt and mTORC1 increase HIF1alpha protein levels and knockdown of cavin-3 progressively increased both HIF1alpha levels and the use of fermentative glycolysis (XREF_FIG)."