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AKT activates MTOR. 10 / 1113
1 | 6 243 811
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"Phosphorylation of PI3K and AKT activates mTOR, a serine/threonine kinase."
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"Therefore, it is reasonable to assume that activation of AMPK was responsible for suppressing AKT mediated mTOR activation in irradiated HHSECs."
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"PI3K triggers Akt which consequently activates mTOR."
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"Prior work has shown that Class I PI3Ks inhibit autophagy by activating AKT, which promotes MTOR signaling, thus suppressing autophagy [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
sparser
"PI3K activation activates Akt which activates mTOR."
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"The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR dependent translation."
sparser
"Subsequently, Akt activates mammalian target of rapamycin (mTOR) and regulates down stream effector p70 ribosomal protein S6 kinase (p70S6K) and 4E-BP1, both of which control protein synthesis (Rommel et al., xref )."
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"Moreover, the activation of mTOR mediated by AKT suppresses GC autophagy during follicular atresia XREF_BIBR."
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"AKT and c-Met co-expression promotes activation of the AKT and mTOR and Ras and MAPK pathways in the mouse liver."
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"Moreover, Akt activation can also activate the mTOR pathway, but its effect is weaker than Ras-Erk pathway XREF_BIBR, XREF_BIBR."
Phosphorylated AKT activates MTOR. 10 / 19
| 4 15
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"Western blot analysis confirmed up-regulation of mTOR downstream signaling including PI3K, p-Akt, p-mTOR, and p-P70S6K (XREF_FIG)."
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"The mTOR activity is mediated by p-AKT."
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"KS lesions almost universally exhibit phosphorylated Akt, which activates mTOR kinase and phosphorylated S6, which is a biomarker for mTOR kinase activity."
sparser
"Considering that mTOR is activated by p-Akt downstream of PI3K, it is likely that the administration of rapamycin would control the protozoan induced apoptosis of endothelial cells and thus block the movement of parasites into the brain."
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"Phosphorylated AKT is known to activate mTOR, which can stimulate glutamine utilization 50, and increases in glutamine concentration can directly modulate the mTOR pathway 51."
sparser
"Following PI3K activation, AKT is phosphorylated and p-AKT can subsequently activate the mechanistic target of rapamycin (mTOR) through direct or indirect interactions, and activated mTOR (p-mTOR) can then regulate cell growth, proliferation, motility, and survival ( xref )."
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"p-AKT may further activate the mTOR and P70S6K signaling pathway, increase the expression of p-P70S6K and increase proliferation and migration of PASMCs."
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"These results indicated that the phosphorylation of Akt induced mTOR activation and led to the phosphorylation of p70S6k and 4E-BP1."
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"Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1 and PD-L1 axis activating intracellular AKT and mTOR pathway in tumor cells."
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"p-Akt has also been shown to promote cell proliferation by regulating the stability of cyclin D1 or activating mTOR."
Kinase-active AKT activates MTOR. 7 / 7
7 |
bel
"growth factors, cytokines and other signalling molecules stimulate HIF-1a synthesis via activation of the phosphatidylinositol 3-kinase (PI3K) or mitogen- activated protein kinase (MAPK) pathways (FIG. 1)."
bel
"mechanical strain of HASM induced a significant increase in hypoxia-inducible factor-1alpha (HIF-1alpha) mRNA and protein, a transcription factor required for VEGF gene transcription; and 5) mechanical strain of HASM induced HIF-1alpha/VEGF through dual phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and ERK pathways."
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
bel
"The mechanism involves the ability of this integrin to stimulate the phosphorylation and inactivation of 4E-binding protein (4E-BP1), a translational repressor that inhibits the function of eukaryotic translation initiation factor 4E (eIF-4E). The regulation of 4E-BP1 phosphorylation by alpha 6 beta 4 derives from the ability of this integrin to activate the PI-3K-Akt pathway and, consequently, the rapamycin-sensitive kinase mTOR that can phosphorylate 4E-BP1."
bel
"Modified assertion"
bel
"Modified assertion"
bel
"Modified assertion"
AKT activates phosphorylated MTOR. 6 / 6
| 6
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"In our study, we found that PI3K-AKT-mTOR pathway proteins in normal rats were expressed at low levels, while there was increased expression of p-AKT, p-mTOR and p-P70S6K in brain tissues of anaesthetized rats treated with PI3K and Akt agonists."
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"Although not addressed by the present study, it is likely that Akt, which is activated by ischemia, 49 activates p-mTOR at S2448."
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"Since Akt promotes oncogenesis by inhibiting apoptosis and promoting proliferation of cancer cells directly as well as indirectly by regulating the activation of NF-kappaB and p-mTOR, we investigated the mechanism by CDDO-Me inhibits Akt."
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"As expected, the MAPK inhibitor U0126 effectively decreased p-ERK1/2 protein expression (0.01 +/-0.01-fold versus 1 +/-0.2-fold vehicle treated, P < 0.001), and the PI3K inhibitor LY294002 decreased p-Akt (0.01 +/-0.01-fold versus 1 +/-0.09-fold vehicle treated), downstream Akt target p-mTOR (0.5 +/-0.2-fold versus 1 +/-0.2-fold vehicle treated), downstream mTOR target p-70S6 kinase (0.02 +/-0.02-fold versus 1 +/-0.1-fold vehicle treated)."
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"Moreover, the combined inhibition of both p38 and Akt in CsA treated animals was more effective and more significantly reduced p-Akt (p = 0.0001), p-p38 (p = 0.02) and p-mTOR as compared to CsA (alone)-treatment group (XREF_SUPPLEMENTARY)."
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"This is in sharp contrast to Hs578T cells where a distinct AKT signal fails to activate p-mTOR S2448 and an activation of pRSK S380 is not promoted in this cell line."
Phosphorylated AKT activates phosphorylated MTOR. 2 / 2
| 2
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"PI-3K was increased up to twofold relative to the naive control (2.35 +/-0.5 vs. 1.00 +/-0.01 of control, p < 0.01) and both p-Akt and p-mTOR were increased nearly three times (p-Akt 2.4 +/-0.63 vs. 1.00 +/-0.02 of control, p < 0.01, and p-mTOR 2.18 +/-0.22 vs. 1.00 +/-0.02 of control, p < 0.01)."
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"Pharmacological inhibition of p-Akt with SH-6 inhibited not only p-Akt but also p-mTOR."
AKT activates MTOR. 1 / 1
1 |
bel
"AKT activates the downstream mTOR kinase by inhibiting a complex formed by the tumor suppressor proteins TSC1 and TSC2, also known as hamartin and tuberin"
Mutated AKT activates MTOR. 1 / 1
| 1
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"A chemical inhibitor of PI3K or a dominant negative mutant of Akt blocks TGF-beta-induced mTOR activation."
AKT bound to MTOR activates MTOR. 1 / 1
| 1
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"The second Akt target, PRAS40, binds the mTOR kinase domain and inhibits mTOR activity."
AKT phosphorylated on S473 activates MTOR. 1 / 1
| 1
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"The data demonstrated the activities on the Akt and mTOR signaling including the phosphorylation of Akt at both Thr308 and Ser473 residues in the activation loop and hydrophobic motif of the kinase, respectively, and phosphorylation of mTOR at Ser2448 that was dependent on the kinase activity [XREF_BIBR, XREF_BIBR]."