"The constitutively activated myristylated Akt reduced ERalpha expression, whereas agents that negatively affect the PI3K and Akt pathway, i.e., wortmannin, celecoxib, and the green tea polyphenol epigallocatechin-3 gallate, induced ERalpha."
"PI3K and AKT pathway activation has been associated with increased ER transcriptional activity and reduced ER expression in MCF-7 cells."
"Inhibition of the PI3K and AKT pathway using AZD5363 or BKM120 induced ERalpha expression."
"Further, AZD5363 treatment increased ER protein levels in the HBCx-3 xenografts [see Additional file XREF_SUPPLEMENTARY, Figure S5D], suggesting that active AKT represses ER expression both in vitro and in vivo."
"Activation of AKT alone is sufficient for PI3-kinase-mediated destabilisation of ERalpha as a constitutively active AKT (CA-AKT) but not kinase-dead AKT (KD-AKT) reduced ERalpha levels (XREF_FIG)."
"Activation of the PI3K and AKT and the p42/44 mitogen activated protein kinases (MAPK) pathways by these receptors, in turn, downregulates the expression of ER and PR."
"In agreement with our data, Guo and colleagues reported that constitutively active AKT reduces ERalpha expression, whereas AKT inhibition increases ERalpha levels [XREF_BIBR]."