IndraLab

Statements


ACVR2A phosphorylates ACVR1B. 1 / 1
1 |

"In this complex, the actrii??/Iib kinase phosphorylates alk4 within a glycine- and serine-rich region called the gs domain, and this phosphorylation event activates the alk4 kinase"
Kinase-active ACVR2A leads to the phosphorylation of ACVR1B. 1 / 1
1 |

"These proteins signal by stimulating formation of specific heteromeric complexes of type I and type II serine/threonine kinase receptors. The type II receptors are encoded by five known mammalian genes, bind to ligands, and phosphorylate and activate the type I receptors, of which there are seven mammalian members (Fig. 1)."