IndraLab

Statements


RET activates ERK. 10 / 32
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eidos
"Using a combination of drug screening and proteomic and biochemical profiling , we identified an adaptive resistance to RET inhibitors that reactivates ERK signaling within hours of drug exposure ."

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"Specifically, GDNF treatment of the DAergic like SH-SY5Y cell line induced long lasting increases in the growth factor 's levels, resulting in long lasting activation of Ret and Ret mediated activation of ERK1/2."

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"Phosphorylation of RET induced ERK activation and the migration of pancreatic cancer cells XREF_BIBR."

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"The authors speculated that in the double mutants, the ERK MAPK pathway might be activated by RET via an alternative pathway involving PLC-gamma, allowing kidney development to proceed normally, and they did not suggest that other signaling molecules might substitute for GDNF under these conditions."

sparser
"18 Our experiments do not address whether RET phosphorylates T185, which will be important in determining whether RET can independently activate ERK or requires additional contributions from another [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"It has been reported that RET activates ERK and JNK signaling pathways [56,57]."

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"Ret induces the serine/threonine kinase AKT and extracellular signal regulated kinase (ERK) signaling which mediate pro survival and neurotrophic activities."

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"Western blot analyses showed that RET inhibition abolishes AKT and ERK1/2 activation."

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"Although the effects of Ret signaling on GIRK2 have not been studied, it is tempting to speculate that the modulation of Ras and Mapk signaling by Ret and DJ-1 also affects GIRK2 function and vulnerability of dopaminergic neurons."

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"PF573228 also inhibited RET- dependent activation of Akt and ERK1/2 in MCF7 cells to a similar degree as SPP86."
Mutated RET activates ERK. 2 / 2
| 2

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"Mice expressing a dominant negative Ret mutation that severely diminishes ERK activity exhibited a variety of anomalies including unilateral agenesis, bilateral hypoplasia, cysts and bilateral agenesis [XREF_BIBR]."

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"Furthermore, p.C630del RET mutant induced strong activation of the MAPK/ERK pathway."
Kinase-active RET activates ERK. 1 / 1
1 |

"However, overexpression of FRS2 but not Shc potentiates mitogen-activated protein (MAP) kinase activation by RET oncoproteins. "