"In these cancers, RET activates the ERK and MAPK, the PI3K/AKT/mTOR and the JAK and STAT3 pathways."
"These results further support that the mechanism of CAKUT pathogenesis in patients with these RET mutations (megaureters, dysplasia and cryptorchidism, and duplication) is at least through modulation of RET activated MAPK activity."
"Lambertz et al. recently described ALK driven upregulation of MAPK regulators and RET in neuroblastoma, and also the RET driven upregulation of cholinergic lineage markers."
"Phosphorylation of RET induced ERK activation and the migration of pancreatic cancer cells XREF_BIBR."
"The authors speculated that in the double mutants, the ERK MAPK pathway might be activated by RET via an alternative pathway involving PLC-gamma, allowing kidney development to proceed normally, and they did not suggest that other signaling molecules might substitute for GDNF under these conditions."
"Consistent with earlier experiments, placing a His tag at the N-terminus was detrimental to the biological activity of GDNF [XREF_BIBR] : there was significant reduction in the ability of His tagged zGDNF to elicit RET induced MAPK signaling (XREF_SUPPLEMENTARY)."
"RET signaling activates ERK or AKT signaling depending on context, but phosphorylation of p70S6 kinase is markedly increased in all cases."
"We have previously shown that SPP86 inhibits GDNF- RET induced activation of the MAPK pathway at low doses [XREF_BIBR]."
"Furthermore, we found that DHA supplementation markedly increased the levels of GDNF and GFRalpha1 and the phosphorylation of RET, and led to the activation of the MAPK pathway in hippocampus tissue."