A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

RET activates ERK. 10 / 50
1 | 2 4 43
"In these cancers, RET activates the ERK and MAPK, the PI3K/AKT/mTOR and the JAK and STAT3 pathways."
"These results further support that the mechanism of CAKUT pathogenesis in patients with these RET mutations (megaureters, dysplasia and cryptorchidism, and duplication) is at least through modulation of RET activated MAPK activity."
"Lambertz et al. recently described ALK driven upregulation of MAPK regulators and RET in neuroblastoma, and also the RET driven upregulation of cholinergic lineage markers."
"Phosphorylation of RET induced ERK activation and the migration of pancreatic cancer cells XREF_BIBR."
"The authors speculated that in the double mutants, the ERK MAPK pathway might be activated by RET via an alternative pathway involving PLC-gamma, allowing kidney development to proceed normally, and they did not suggest that other signaling molecules might substitute for GDNF under these conditions."
"Consistent with earlier experiments, placing a His tag at the N-terminus was detrimental to the biological activity of GDNF [XREF_BIBR] : there was significant reduction in the ability of His tagged zGDNF to elicit RET induced MAPK signaling (XREF_SUPPLEMENTARY)."
"RET signaling activates ERK or AKT signaling depending on context, but phosphorylation of p70S6 kinase is markedly increased in all cases."
"We have previously shown that SPP86 inhibits GDNF- RET induced activation of the MAPK pathway at low doses [XREF_BIBR]."
"Furthermore, we found that DHA supplementation markedly increased the levels of GDNF and GFRalpha1 and the phosphorylation of RET, and led to the activation of the MAPK pathway in hippocampus tissue."
"18 Our experiments do not address whether RET phosphorylates T185, which will be important in determining whether RET can independently activate ERK or requires additional contributions from another [MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
Mutated RET activates ERK. 3 / 3
| 3
"In papillary thyroid cancer, RET mutations that activate the tyrosine kinase domain of RET and consequently induce the MAPK pathway, PI3K pathway, and STAT pathway, as well as other signaling pathways are common."
"Activated RET mutant proteins also enhance MAPK signaling."
"Mice expressing a dominant negative Ret mutation that severely diminishes ERK activity exhibited a variety of anomalies including unilateral agenesis, bilateral hypoplasia, cysts and bilateral agenesis [XREF_BIBR]."
Kinase-active RET activates ERK. 1 / 1
1 |
"However, overexpression of FRS2 but not Shc potentiates mitogen-activated protein (MAP) kinase activation by RET oncoproteins. "
RET bound to ptc activates ERK. 1 / 1
| 1
"The ligand independent dimerization of RET and PTC protein leads to chronic stimulation of MAPK and PI3K-AKT signaling and increased cell proliferation and transformation in thyroid cells [XREF_BIBR, XREF_BIBR]."