A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

RAF1 phosphorylates MAPK1. 3 / 4
| 1 2
reach
"Here, we show that both HCV genotype 1a and 3 core proteins activate MEK1 and Erk1/2 MAP kinases and that the costitutive expression of the HCV core results in a high basal activity of Raf1 and MAP/kinase/kinase, as determined by endogenous Raf1 in vitro kinase assay and immunodetection of hyperphosphorylated Erk1 and Erk2 even after a serum starvation."
rlimsp
"Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases, ERK1 and ERK2."
reach
"Raf-1 is activated by Ras inducing MEK1, ERK1, and ERK2 phosphorylation [XREF_BIBR], while MST2 triggers apoptosis through PUMA and caspases activation."
Kinase-active RAF1 leads to the phosphorylation of MAPK1 on T185. 2 / 2
2 |
bel
"To address a possible role of mutant C-RAF proteins in the constitutive phosphorylation of ERK1/2, kinase assays were done with Myc-tagged C-RAF proteins immunoprecipitated from transiently transfected Cos-7 cells. Strong constitutive kinase activity was shown for S427GC-RAF whereas I448VC-RAF did not significantly differ from wt C-RAF (Fig. 3A)."
bel
"Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2."
RAF1 phosphorylates MAPK1 on Y187. 2 / 2
2 |
biopax:pid
No evidence text available
biopax:pid
No evidence text available
RAF1 phosphorylates MAPK1 on T185. 2 / 2
2 |
biopax:pid
No evidence text available
biopax:pid
No evidence text available
Kinase-active RAF1 leads to the phosphorylation of MAPK1 on Y187. 2 / 2
2 |
bel
"To address a possible role of mutant C-RAF proteins in the constitutive phosphorylation of ERK1/2, kinase assays were done with Myc-tagged C-RAF proteins immunoprecipitated from transiently transfected Cos-7 cells. Strong constitutive kinase activity was shown for S427GC-RAF whereas I448VC-RAF did not significantly differ from wt C-RAF (Fig. 3A)."
bel
"Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2."
Kinase-active RAF1 phosphorylates MAPK1. 1 / 1
1 |
bel
"Plasma membrane-targeted Raf-1 did not protect from apoptosis and resulted in phosphorylation of ERK-1 and ERK-2"
RAF1 phosphorylates MAPK1 on S29. 1 / 1
1 |
hprd
No evidence text available