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RAF1 inhibits MAPK1. 4 / 5
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"Overexpression of full-length p74raf-1 rescued the inhibition of ERK2 by N delta raf in a stimulus dependent manner, indicating that N delta raf acts as a competitive inhibitor of wild-type p74raf-1."
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"Although the precise mechanism bywhich the dominant negative mutant inhibited Raf-1 function was not clear, further work suggested that the amino-terminal half of the Raf-1 protein interacted with a p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the present work we show that expression of the Raf-1 autoinhibitory domain blocks extracellular signal regulated kinase 2 activation by the Raf-1 catalytic domain in mammalian cells."
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"For instance, by inhibiting the action of a single molecule such as BRAF (B-Raf proto-oncogene, serine/threonine kinase), the entire RAF/MEK/ERK (Raf-1 proto-oncogene, serine/threonine kinase, mitogen activated protein kinase kinase 1, mitogen activated protein kinase 1) pathway will be tuned down, and as a consequence, collateral pathways including PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) and RALA (v-ral simian leukemia viral oncogene homolog A (ras related)) will also be affected."
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RAF1 phosphorylated on S259 inhibits MAPK1. 1 / 1
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"This inhibitory phosphorylation on Raf reduces the activity of MAPK pathway (Zimmermann and Moelling, 1999)."
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