A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

RAF1 inhibits MAPK1. 3 / 4
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"In the present work we show that expression of the Raf-1 autoinhibitory domain blocks extracellular signal regulated kinase 2 activation by the Raf-1 catalytic domain in mammalian cells."
"Overexpression of full-length p74raf-1 rescued the inhibition of ERK2 by N delta raf in a stimulus dependent manner, indicating that N delta raf acts as a competitive inhibitor of wild-type p74raf-1."
"For instance, by inhibiting the action of a single molecule such as BRAF (B-Raf proto-oncogene, serine/threonine kinase), the entire RAF/MEK/ERK (Raf-1 proto-oncogene, serine/threonine kinase, mitogen activated protein kinase kinase 1, mitogen activated protein kinase 1) pathway will be tuned down, and as a consequence, collateral pathways including PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) and RALA (v-ral simian leukemia viral oncogene homolog A (ras related)) will also be affected."
RAF1 phosphorylated on S259 inhibits MAPK1. 1 / 1
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"This inhibitory phosphorylation on Raf reduces the activity of MAPK pathway (Zimmermann and Moelling, 1999)."