A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



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PTK6 activates STAT3. 10 / 40
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"siRNA-mediated reduction of endogenous Cbl expression resulted in a significant enhancement of Brk-induced STAT3-LUC activation in these cells ( Fig. 3 D, upper panel)."
"Although characterization of PTK6 in the normal gastrointestinal tract suggested that it might function as a tumor suppressor, recent in vivo studies demonstrated that disruption of Ptk6 impairs STAT3 activation and subsequent tumorigenesis following carcinogen administration."
"In addition, small interfering RNA mediated reduction of endogenous STAP-2 expression strongly decreased Brk mediated STAT3 activation in T47D breast cancer cells."
"PTK6 phosphorylates and activates STAT3 in cell lines and increased STAT3 activation was observed in Ptk6 +/+ mice, compared with Ptk6 -/- mice, after AOM administration."
"PTK6 promotes STAT3 activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 activity in mouse colon tumors and in the HCT116 and YAMC cell lines."
"STAT3 has been shown to promote tumor initiation of different tumor types, including those of the gastrointestinal tract and skin, and PTK6 was previously shown to promote STAT3 activation and tumorigenesis in mouse models of colon and skin cancer."
"Silencing PTK6 reduced ERK1/2 activation, but not AKT or STAT3 activation, while PTK6 overexpression increased ERK1/2 activation."
"PTK6 activates STAT3 [ xref ] and STAT5b [ xref ] to promote proliferation, and this may be facilitated by the signal transducing adaptor protein-2 (STAP2) [ xref ]."
"One of STAT3 target gene products is the suppressor of cytokine signaling 3 (SOCS3), which was recently shown to inhibit BRK induced activation of STAT3 XREF_BIBR."
"Importantly, small interfering RNA mediated reduction of endogenous STAP-2 expression decreased Brk mediated STAT3 activation."
Kinase-active PTK6 activates STAT3. 1 / 1
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"In this study, we provide evidence that the signal transducer and activator of transcription 3, STAT3, is a physiological target of Brk. results in this study demonstrate that STAT3 is tyrosine phosphorylated and transcriptionally activated in cells expressing endogenous Brk. Signal transducer and activator of transcription 3 activation requires the catalytic activity of Brk "
Active PTK6 activates STAT3. 1 / 1
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"In contrast, overexpression of constitutively active PTK6 promoted STAT3 and ERK5 activation in colon cancer cells, and endogenous PTK6 promoted cell survival and oncogenic signaling in response to DNA-damaging treatments."