IndraLab

Statements

PTEN decreases the amount of PTEN. 10 / 108
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"Bioinformatics analysis using the STITCH database predicted that ETO could interact with WWP2 and PTEN by upregulating the protein expression of WWP2 and downregulating the protein expression of PTEN."
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"Notably, suppressing FAPalpha in oral squamous cancer cells significantly decreased the expression of phosphorylated phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT), mitogen activated protein kinase kinase 1/2 and extracellular signal regulated kinase (ERK) 1/2, and upregulated the expression of phosphatase and tensin homolog (PTEN)."
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"Decreased PTEN expression did not reduce RAD51 expression or clonogenic survival following PARPi among prostate cancer cells that vary in TP53 and PTEN."
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"Together, these data illustrate that the Pten m3m4 mutation results in decreased Pten nuclear localization and decreased Pten overall expression and leads to dysregulation in downstream canonical signaling in NSCs."
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"These results demonstrate that PTEN negatively regulates HBV replication, implying that HBV reduces PTEN expression to upregulate proviral activity."
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"Moreover, SNHG20 was confirmed to interact with PTEN, which negatively regulated PTEN protein level."
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"On the other hand, lnc-DILC recruited deubiquitinase USP11 to PTEN, thus reducing the ubiquitination level of PTEN."
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"Specifically, phosphatase and tensin homolog small interfering RNA (ExoPTEN)-loaded exosomes reduced the expression of PTEN, thereby improving structural and electrophysiological function in spinal cord injury."
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"The latter is in line with the rate of up to 50% PTEN " reduced expression " previously reported in conventional urothelial carcinoma [XREF_BIBR, XREF_BIBR] and our prior study finding of low H score of PTEN expression in urothelial carcinoma with divergent histology [XREF_BIBR]."
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"By western blot analysis, we observed that PTEN inhibited basal AKT phosphorylation, but not ERK1/2 phosphorylation in PTEN expressing cells."
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Modified PTEN decreases the amount of PTEN. 6 / 6
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"Immunohistochemistry for PTEN on the PTEN-mutant, MSI-H tumors showed 4/9 (44%) of exon 8 mutants lost expression of PTEN (XREF_FIG), where the two exon 7 mutants had only diminished PTEN expression."
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"Therefore, moderate changes of PTEN levels elicited by loss of PTEN ceRNA expression are likely to contribute to melanomagenesis in the context of a B-Raf V600E initiating mutation."
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"In addition, the protein level of PTEN was also elevated by GAS5 overexpression; however, the GAS5 induced increase in PTEN protein expression was suppressed markedly by miR-32-5p overexpression, suggesting that miR-32-5p negatively regulated the expression of PTEN and mediated the effect of GAS5 on PTEN expression."
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"PTEN expression was markedly decreased in diabetic kidneys while XST partly restored PTEN expression."
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"The results showed that loss of PTEN and upregulation of Akt in and treatment with HO-3867 significantly restored PTEN levels and caused downregulation of Akt."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR PTEN expression has also been shown to be downregulated by TGFbeta1 in keratinocytes, XREF_BIBR and PTEN mRNA levels were also reduced in a model of TGFbeta1 overexpressing transgenic mice that develop pancreatic fibrosis."
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Methylated PTEN decreases the amount of PTEN. 5 / 5
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"Our results strongly suggest that CpG hypermethylation of the PTEN gene contributes to the decreased expression of PTEN during acquired resistance to gefitinib or erlotinib."
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"Hypermethylation of the PTEN promoter in somatic cells downregulates PTEN expression."
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"The hypermethylation of the PTEN promoter reduces PTEN expression and leads to overactivation of the PI3K pathway ."
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"Previous studies have shown that PTEN promoter methylation can directly reduce PTEN expression in HSCs [20, 22, 31]."
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"These results indicate that the hypermethylation of the PTEN promoter region leads to lower expression of PTEN gene in ACC cells, which aids in the development of PTEN as a molecular marker for the early diagnosis of this carcinoma."
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Mutated PTEN decreases the amount of PTEN. 4 / 4
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"The involvement of PTEN in human mammary oncogenesis has been implicated from studies showing that germline PTEN mutation in Cowden disease predisposes to breast cancer, the frequent loss of heterozygosity at the PTEN locus, and reduced PTEN protein levels in sporadic breast cancers."
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"In the PCa epithelia, PTEN mutation and loss of heterozygosity significantly reduce PTEN protein levels and thereby negate the tumor suppressive properties of nuclear PTEN."
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"However, at a later time point in fracture healing when mature osteoblasts that produce osteocalcin were present, the Pten mutants had decreased Pten expression, and increased ossification, as shown by the increased thickness of bone at the proximal and distal ends of the callus."
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"Interestingly, we found that mutation of the PTEN Tyr 155 residue significantly increased the association of WWP2 with PTEN, followed by enhanced polyubiquitylation and reduced PTEN protein levels (XREF_FIG), indicating that some yet-to-be-identified tyrosine kinases may be involved in the regulation of the WWP2-PTEN interaction."
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PTEN bound to miR-130b decreases the amount of PTEN. 1 / 1
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"Our study shows that miR-130b binds the 3 '-UTR of PTEN mRNA to downregulate PTEN protein expression, thus promoting Akt phosphorylation."
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PTEN-G129E decreases the amount of PTEN-G129E. 1 / 1
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"The modulation of intracellular PI (3,4,5) P 3 levels through overexpression of PTEN or a lipid phosphatase deficient mutant PTEN (G129E) was also observed to significantly reduce or elevate macropinosome formation respectively; coexpression of PTEN (G129E) with SNX9 or SNX18 synergistically elevated macropinosome formation to 119.4 +/-7.13 and 91.4 +/-6.37 macropinosomes respectively (p < 0.05)."
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PTEN-C136Y decreases the amount of PTEN. 1 / 1
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"From mutations file"
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PTEN-R173C decreases the amount of PTEN. 1 / 1
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"From mutations file"
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