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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

PTEN leads to the phosphorylation of IRS1. 5 / 5
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reach
"The effect of TNF on insulin promoted tyrosine phosphorylation of IRS-1 was blocked by inhibition of PI 3-kinase and the PTEN tumor suppressor, which dephosphorylates the lipids that mediate PI 3-kinase functions, whereas constitutively active Akt impaired insulin promoted IRS-1 tyrosine phosphorylation."
sparser
"Consistently with such feedback regulation, stable knockdown of PTEN enhanced IRS1 phosphorylation only minimally in NEDD4 −/− MEFs, although it substantially restored IGF1-induced AKT activation, presumably by suppressing the PIP3 phosphatase activity of PTEN ( xref )."
reach
"Moreover, PTEN inhibits insulin signaling by indirectly suppressing the phosphorylation of mitogen activated protein kinase (MAPK) and blocking insulin receptor substrate 1 (IRS-1) phosphorylation [XREF_BIBR]."
reach
"PTEN silencing increased the phosphorylation of AKT and the expression of PI3K but decreased the phosphorylation of IRS1, which increased the phosphorylation levels of glycogen synthase kinase-3beta (GSK-3beta) and expression of sterol regulatory element binding protein-1c (SREBP-1c)."
reach
"Our data suggest that PTEN blocks MAPK phosphorylation in response to insulin stimulation by inhibiting the phosphorylation of IRS-1 and IRS-1, Grb2, and Sos complex formation, which leads to downregulation of cyclin D1, inhibition of cell cycle progression and suppression of cell growth."
Phosphatase-active PTEN leads to the phosphorylation of IRS1 on serine. 1 / 1
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bel
"The latter was accompanied by a decrease in the phosphorylation of insulin receptor substrate 1 (IRS-1) and the association of IRS-1 with Grb2/Sos"
PTEN leads to the phosphorylation of IRS1 on tyrosine. 1 / 1
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reach
"The effect of TNF on insulin promoted tyrosine phosphorylation of IRS-1 was blocked by inhibition of PI 3-kinase and the PTEN tumor suppressor, which dephosphorylates the lipids that mediate PI 3-kinase functions, whereas constitutively active Akt impaired insulin promoted IRS-1 tyrosine phosphorylation."
Modified PTEN leads to the phosphorylation of IRS1 on S307. 1 / 1
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reach
"A recent study identified that HCV infection may lower the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), which in turn increases phosphorylation of IRS1 at Ser307 and inhibits the PI3K and Akt signaling pathway, leading to insulin resistance."
PTEN leads to the phosphorylation of IRS1 on S307. 1 / 1
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reach
"In addition, we also demonstrated that depletion of PTEN accelerated degradation of IRS-1 and promoted Ser307 phosphorylation of IRS-1, indicating that the balance between IRS-1 and pIRS-1 at Ser307 was PTEN dependent."