A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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PTEN inhibits MTOR. 8 / 170
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"Interestingly, it has been shown recently that loss of Pten induces ER UDPase ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), and activation of the AKT and mTOR pathway leads to induction of pyruvate kinase isoenzyme type M2 (PKM2), which contribute to aerobic glycolysis, also known as the Warburg effect, and tumor growth in a xenograft model of prostate cancer."
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"Loss of PTEN, which is a tumor-suppressor gene that inhibits the PI3K/AKT/mTOR pathway, causes the aberrant mTOR pathway activation."
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"Loss of PTEN also activates the mTOR pathway, causing senescence [XREF_BIBR]."
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"In addition, the PTEN gene can inhibit mTOR activity by negatively regulating the PI3K and Akt signaling pathway, therefore inhibiting cancer cell proliferation, promoting apoptosis and reversing multidrug resistance."
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"It has been reported that ERbeta can regulate mTOR activation via multiple mechanisms, such as increasing PTEN expression and decreasing phosphorylation of AKT [XREF_BIBR, XREF_BIBR]."
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"The present study showed that overexpression and knockdown of PTEN led to inactivation and activation of mTOR and GSK-3beta, respectively, and overrode the effect of miR-19a on axonal outgrowth."
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"Mester et al. found that the increase in PTEN expression inhibited the Akt and mTOR signaling pathway, leading to cell death and growth regulation 40."
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"Thus PTEN, by suppressing PI3K and Akt signaling, also suppresses the downstream mTOR kinase activity."
PTEN inhibits phosphorylated MTOR. 4 / 4
| 4
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"In human hepatocellular carcinoma, PTEN loss and overexpression of p-AKT and p-mTOR were correlated with TNM stage, vascular invasion, intrahepatic metastasis, tumor grade, and Ki-67 high expression, and PTEN loss was associated with p-AKT, p-mTOR, and MMP-9 overexpression [XREF_BIBR]."
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"The overexpression of miR-486 inhibited the expression of PTEN both at the mRNA and protein levels and thus increased the levels of AKT, phosphorylated AKT, mTOR and phosphorylated mTOR."
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"In HCC, PTEN loss and overexpression of p-AKT and p-mTOR were associated with tumor grade, intrahepatic metastasis, vascular invasion, TNM stage and high Ki-67 labeling index (P < 0.05)."
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"We found that MTE treatment increased PTEN level and decreased p-AKT and AKT and p-mTOR and m-TOR."
Phosphatase-active PTEN inhibits MTOR. 1 / 1
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"Loss of PTEN function leads to an elevated concentration of the PIP3 substrate, and consequent constitutive activation of downstream components of the PI3K pathway, including the AKT and mTOR kinases"
Modified PTEN inhibits MTOR. 1 / 1
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"In addition, overexpression of PTEN was able to partially inhibit Cd induced activation of Akt and mTOR, and apoptosis of the cells."