A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

PTEN inhibits AKT1. 4 / 81
2 | 28
reach
"By opposing PI3K signaling, PTEN inhibits the activation of the critical PI3K effector proteins Akt1-3 (also known as protein kinase B or PKB)."
signor
"Exposure of eol-1r cells to imatinib failed to dephosphorylate akt, erk and stat5, although pdgfralpha was effectively inactivated. The forced expression of pten negatively regulated these signal pathways and sensitized eol-1r cells to imatinib."
reach
"On the other hand, AKT1 is negatively regulated by PTEN, a p53 response gene that is inactivated in a variety of cancers XREF_BIBR."
reach
"Phosphatase and tensin homolog (PTEN) negatively regulates downstream protein kinase B signaling, resulting in decreased cellular growth and proliferation."
PTEN inhibits mutated AKT1. 3 / 3
| 3
reach
"The vast majority of cases (69% of pure DCIS and 75% of DCIS adjacent to IBC) harboring PTEN or INPP4B loss of expression, or PIK3CA or AKT1 mutations, displayed pAKT expression, whereas pS6 expression was found in 6% and 21% of pure DCIS and DCIS adjacent to IBC harboring these molecular aberrations."
reach
"Genomic alterations included in the PRESSING panel were investigated as previously reported, XREF_BIBR thus exploring several uncommon anti-EGFR resistance mechanisms beyond RAS and BRAF mutations (ie, HER2 amplification and activating mutations; MET amplification; NTRK/ROS1/ALK/RET rearrangements; PIK3CA exon 20 mutations, PTEN inactivating mutations, AKT1 mutations)."
reach
"In conclusion, here we demonstrate that PTEN and INPP4B loss of expression, PIK3CA hotspot mutations, and AKT1 mutations are found in a subset of pure high-grade DCIS and high-grade DCIS adjacent to IBC, that the prevalence of alterations affecting these genes vary more according to the ER/HER2 subtype of DCIS than to its association with synchronous IBC."
PTEN inhibits AKT1. 1 / 1
1 |
bel
"Modified assertion"