A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

Phosphatase-active PTEN decreases the amount of EGF bound to EGFR and GAB1. 1 / 1
1 |
bel
"expression of the gene for the lipid phosphatase PTEN, which dephosphorylates PtdIns(3,4, 5)P3, inhibits EGF signaling and translocation of Gab1 to the plasma membrane."
PTEN decreases the amount of EGF. 1 / 1
| 1
reach
"Specifically, stromal PTEN deletion upregulates fibroblast specific EGF ligand expression and subsequent paracrine activation of adjacent epithelial EGFR and ErbB2 signaling."
Modified PTEN decreases the amount of EGF. 1 / 1
| 1
reach
"We provide evidence that loss of PTEN expression rather than upregulated EGF and IGF1 receptor expression was responsible for increased p-Akt in neoplastic prostate cells."