IndraLab

Statements

PTEN activates TP53. 10 / 95
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"Meanwhile, TMOC up-regulated the expression levels of PTEN in all of the three cell lines, but only up-regulated p53 in A2780 cells."
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"Second, PTEN can also compete with MDM2 binding, and thereby block p53 degradation [22,23]."
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"A contrasting role is observed in CML and B cell lineage (B-ALL)-like leukemia, where PTEN causes FOXO dependent upregulation of p53 suppressor Bcl6, allowing ALL and CML cells to escape p53- and p21 mediated cellular senescence [XREF_BIBR]."
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"Nuclear PTEN, independent of its phosphatase activity, leads to p53 mediated G (1) growth arrest, cell death, and reduction of reactive oxygen species production."
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"Importantly, elevated serum HBsAg and ALT levels were seen in HBV transgenic mouse following sgp53 and Pten dual cassette induced p53 and Pten deficiency in mouse livers."
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"Inactivation of Pten in the prostate of mice induces the onset of precancerous high-grade prostatic intraepithelial neoplasia (HG-PIN) and p53 dependent senescence XREF_BIBR."
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"PTEN plays an important role in regulating p53 protein levels and activity; loss of PTEN may decrease the selective pressure on tumors to lose p53 during cancer progression.In an attempt to further de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We revealed that the downregulation of p21 is necessary for apoptosis induction and PTEN promotes apoptosis by amplifying p53 activation."
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"As discussed above, activation of PI3K (Pten)-Akt activates p53 and activated p53 inhibit PI3K (Pten)-Akt (XREF_FIG)."
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"This study provides evidence that PTEN can modulate p53 function independently of its phosphatase activity, and that a physical interaction between PTEN and p53 is important for this modulation in viv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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PTEN activates mutated TP53. 2 / 2
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"In PBK and TOPK overexpressing GC cells, knockdown of PBK and TOPK inhibited the cell proliferation through the p53 activation in a TP53 mutation dependent manner and inhibited the migration and invasion through the PTEN upregulation in a TP53 mutation independent manner."
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"We confirmed the interactions of IPMK and PTEN with stress-induced p53 and mutant p53 by co-IP (Fig. 4f, g and Extended Data Fig. 3i)."
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PTEN bound to TP53 activates TP53. 2 / 2
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"PTEN interacts with p53 and enhances p53 stability, resulting in cell cycle arrest and apoptosis [XREF_BIBR]."
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"Nuclear PTEN binds p53 in a phosphatase independent manner to promote p53 stabilization, thus promoting PTEN transcription [XREF_BIBR]."
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Phosphatase-active PTEN activates TP53. 1 / 1
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"Modified assertion"
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PTEN bound to TP53 activates TP53. 1 / 1
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"PTEN enhances p53 transactivation, a relationship that requires the interaction between PTEN and p53 and is PTEN phosphatase independent."
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