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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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PRL phosphorylates STAT5. 10 / 125
2 | 1 70 52
sparser
"This ninein-dependent inhibition of JAK2 significantly decreases prolactin- and interferon gamma (IFN-γ)-induced tyrosyl phosphorylation of STAT1 and STAT5."
sparser
"It has been shown that prolactin stimulates the phosphorylation of STAT5, which then binds to the promoter of beta-casein gene and participates in its transcriptional activation [37] ."
reach
"We show that in the presence of LrBM, Prl promotes STAT5 phosphorylation in a clathrin dependent, caveolin independent manner that requires Rab5b."
sparser
"Enhanced and sustained prolactin-induced Stat5 tyrosine phosphorylation was observed in T47D and MCF7 breast cancer cells selectively in response to PTP1B depletion."
reach
"In the present study, we show that prolactin induces phosphorylation of ERK1/2 and STAT5 and induces tube formation of endothelial cells on Matrigel."
sparser
"The activity of the PrlRA to block Prl-induced STAT5 phosphorylation was subsequently studied by exposing cells to different concentrations of the PrlRA followed by the addition of 100 ng/ml Prl."
reach
"Nuclear Stat5 phosphorylation was highly induced by Prl in the controls expressing LF only (lane 2 vs lane 1)."
sparser
"No effects on the activity of arcuate kisspeptin neurons were observed, despite a high percentage (70%) of arcuate neurons expressing prolactin-induced STAT5 phosphorylation."
sparser
"In both cases, blocking the action of Rok enhanced prolactin receptor expression ( xref A), as well as prolactin-induced Stat5 phosphorylation ( xref B) and β-casein expression ( xref A,C)."
reach
"PRL treatment in MCF-12A cells increased levels of beta-casein and phosphorylated STAT5 (pSTAT5) proteins in a concentration dependent manner, with a slight increase of STAT5 protein."
PRL leads to the phosphorylation of STAT5 on tyrosine. 5 / 5
| 5
reach
"Formation of this complex and tyrosine phosphorylation of STAT5 in response to prolactin requires the SH2 domain closer to the C-terminus and the catalytic activity of Shp-2."
reach
"Prolactin stimulation of transfected cells induces Stat5 phosphorylation on tyrosine."
reach
"STAT-5 tyrosine phosphorylation was similarly induced by PRL and IL-3, with an additive effect detected in the presence of both stimuli."
reach
"Prolactin does not induce tyrosine phosphorylation of its receptor, Jak2, or Stat5 in nondifferentiated breast epithelia cultured on collagen I, and we show that this is due to a vanadate sensitive activity that inhibits the prolactin pathway."
reach
"We find that PRL stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the serine protease inhibitor (Spi) 2.1 promoter, and activated Spi 2.1 gene expression."
PRL leads to the phosphorylation of STAT5 on Y694. 1 / 1
| 1
reach
"Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription."