"Formation of this complex and tyrosine phosphorylation of STAT5 in response to prolactin requires the SH2 domain closer to the C-terminus and the catalytic activity of Shp-2."
"Prolactin stimulation of transfected cells induces Stat5 phosphorylation on tyrosine."
"STAT-5 tyrosine phosphorylation was similarly induced by PRL and IL-3, with an additive effect detected in the presence of both stimuli."
"Prolactin does not induce tyrosine phosphorylation of its receptor, Jak2, or Stat5 in nondifferentiated breast epithelia cultured on collagen I, and we show that this is due to a vanadate sensitive activity that inhibits the prolactin pathway."
"We find that PRL stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the serine protease inhibitor (Spi) 2.1 promoter, and activated Spi 2.1 gene expression."