A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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PRL activates STAT5. 10 / 281
| 3 86 171
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"In mammary glands, PRL activated Stat5 in a majority of luminal epithelial cells but not myoepithelial cells, stromal fibroblasts, or adipocytes, whereas GH activated Stat5 in a significant fraction of myoepithelial cells, fibroblasts, and adipocytes but only in a minority of luminal cells."
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"We showed previously that PRL, via Jak2, induces binding of Stat5 to a distal GAS site (GAS1) in the cyclin D1 promoter."
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"Thus, our data show that beta1 integrin is critical for the Prl induced activation of Stat5, a transcription factor essential for mammary epithelial differentiation, and they provide genetic evidence for cooperation between integrin and cytokine signaling pathways."
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"In DG-/- cells, Prl failed to induce the sustained activation of STAT5 even in the presence of lrECM (XREF_FIG)."
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"Interestingly, PRL but not GH activated Stat5 in nearly all of the endocrine glands."
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"Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects."
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"Like crosstalk downstream of PRLR and EGFR, PRL and IGF-I cooperatively activate ERK1/2 and AKT, but not STAT5."
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"A ligand induced mechanism for activation of Stat5 in prostate cancer was suggested by the ability of prolactin (Prl) to stimulate activation of both Jak2 and Stat5 in CWR22Rv human prostate cancer cells and in CWR22Rv xenograft tumors."
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"Stat5 is activated by prolactin, and its presence is mandatory for the proliferation and differentiation of mammary epithelium during pregnancy."
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"We have found that in HC11 cells, Stat5 is specifically activated by PRL treatment, demonstrating that Stat5 is a physiological substrate downstream of PRLR."
PRL activates STAT5. 3 / 3
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bel
"STAT3 is activated by many interleukins, IFNg,c-Kit, SCF, GCSF and EGF (for a review, see Heinrich et al., 2003) similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF."
bel
"We first demonstrated that STAT5 and STAT3 could be activated by either hGH or hPRL in T-47D breast cancer cells."
bel
"We demonstrate that SOCS-7 inhibits prolactin (PRL), growth hormone (GH), or leptin (LEP) signaling mediated through STAT3 and STAT5"
PRL bound to Prl Receptor activates STAT5. 1 / 1
| 1
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"In mammary cells, Prl binds to the cytokine cell surface Prl Receptor (PrlR) and activates the Jak2 and Stat5, Map Kinase, and PI3K-Akt signaling pathways [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
PRL bound to PPIB activates STAT5. 1 / 1
| 1
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"In the nucleus, the CypB and prolactin complex interacts with and activates the Stat5 transcription factor."
PRL bound to hGH activates STAT5. 1 / 1
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"Locally secreted hGH binds to prolactin receptors on beta cells, activates STAT5 signaling, and induces pregnancy like changes in gene expression, thereby augmenting pancreatic beta cell mass and insulin content."